The FDA adverse-event record for dog

Dog Adverse Event Insights

The FDA Center for Veterinary Medicine database holds 781,226 adverse event reports for Dog, distributed across 380 distinct breeds currently tracked in the system. Of those reports, 33,500 involved a death outcome, producing a 4.3% case-fatality rate among reported events, which reflects reporting severity bias rather than true population mortality. These figures are aggregated directly from openFDA's Animal & Veterinary Adverse Events endpoint and update as new voluntary submissions flow through pet owners, veterinarians, and drug manufacturers.

The most frequently reported clinical signs for Dog are Vomiting (156,330 reports), Lethargy (see also Central nervous system depression in 'Neurological') (65,152 reports), Emesis (63,375 reports), Diarrhoea (55,562 reports), with Vomiting leading the reaction traffic at 156,330 submissions. On the product side, Milbemycin Oxime + Spinosad is the single most-referenced drug with 138,407 reports, followed by Ivermectin + Pyrantel As Pamoate Salt (82,476), Spinosad (50,664), Afoxolaner (49,011). This combination surfaces which therapeutic classes generate the most adverse event chatter for this species, a useful starting point when comparing Dog reporting patterns against other companion animals in the dataset.

Of the 723,254 Dog reports with a coded outcome, Outcome Unknown accounts for the largest share at 33.8%. Annual submission volume spans 2,010 to 2,025 reports across the 16 years on file, a range that reflects evolving owner awareness, veterinary reporting habits, and new product approvals rather than stable underlying incidence. The breed-level table below breaks these patterns down further, showing how the 380 tracked dog breeds compare on volume, deaths, and average age at report. As with all FDA adverse event data, correlation is the ceiling, causation requires clinical investigation beyond what these aggregates can provide.