Total Reports
2,087
FDA CVM filings
Dog /
2026 FDA CVM data 2,087 reports on file official source
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) — FDA Adverse Event Profile
Adverse-event records and label data for Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) (Dog), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) (Dog) has 2,087 FDA adverse event reports on record, with 91 deaths reported (440.0% death rate) — ranking #79 by report volume. The most frequently reported reaction is Vomiting (521 cases). The top associated drug is Milbemycin Oxime + Spinosad. Average age at report: 6.7 years.
Deaths Reported
91
of 2,087 reports
Death Rate
440.0%
death-coded share
Avg Age at Report
6.7 yr
5.0 kg avg weight
Death-Coded Outcome Share
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) death-coded reports 100.0%
Database median
440.0% of 2,087 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 5.0 kg (11.0 lbs)
Top Reported Reactions
Vomiting 521
Lethargy (see also Central nervous system depression in 'Neurological') 241
Emesis 201
Lack of efficacy (ectoparasite) - flea 196
Diarrhoea 190
Anorexia 108
Seizure NOS 107
Lack of efficacy - NOS 100
Behavioural disorder NOS 77
Pruritus 70
Other abnormal test result NOS 62
Decreased appetite 58
Lack of efficacy (endoparasite) - hookworm 54
Panting 53
Not eating 51
Most Referenced Drugs
Milbemycin Oxime + Spinosad 391
Spinosad 222
Afoxolaner 152
Ivermectin + Pyrantel As Pamoate Salt 136
Fluralaner Chew Tablets 113
Pyrantel Pamoate;Sarolaner 77
Selamectin 66
Imidacloprid + Moxidectin 60
Moxidectin 55
Oclacitinib Maleate 51
Fluralaner 13.64% 12-Week Chew 50
Milbemycin Oxime + Praziquantel 46
Maropitant Citrate 43
Sarolaner 42
Ivermectin, Pyrantel 37
Outcome Breakdown
Recovered/Normal
782 (41.1%)
Outcome Unknown
557 (29.3%)
Ongoing
385 (20.3%)
Recovered with Sequela
86 (4.5%)
Died
57 (3.0%)
Euthanized
34 (1.8%)
Gender Distribution
Female 1,025 (49.1%)
Male 1,012 (48.5%)
Unknown 48 (2.3%)
Mixed 2 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 107 | |
| 2011 | 126 | |
| 2012 | 175 | |
| 2013 | 195 | |
| 2014 | 164 | |
| 2015 | 184 | |
| 2016 | 176 | |
| 2017 | 138 | |
| 2018 | 161 | |
| 2019 | 128 | |
| 2020 | 103 | |
| 2021 | 97 | |
| 2022 | 73 | |
| 2023 | 96 | |
| 2024 | 74 | |
| 2025 | 90 | |
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) Pet Health Insights
Across the FDA Center for Veterinary Medicine adverse event database, Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) accounts for 2,087 submitted reports and currently ranks #79 by report volume within the dog population. Of those reports, 91 involved a death outcome — a 440.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 6.7 years, with an average recorded body weight of 5.0 kg (11.0 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.
The most frequently reported clinical signs for Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) are Vomiting (521 reports), Lethargy (see also Central nervous system depression in 'Neurological') (241 reports), Emesis (201 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Milbemycin Oxime + Spinosad appears in 391 reports and is the single most-referenced drug, followed by Spinosad (222) and Afoxolaner (152). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same dog species.
Outcome coding on the 1,901 reports with a recorded status is dominated by Recovered/Normal (41.1% of coded outcomes). Annual submission volume ranges from 2,010 to 2,025 reports across the 16 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual dog.
Understanding Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) Adverse Event Data
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) has a moderate volume of adverse event reports (2,087). Report counts are influenced by breed popularity, owner awareness, and veterinary reporting practices.
The 440.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.
The most frequently referenced drug in adverse reports is Milbemycin Oxime + Spinosad, appearing in 391 reports. This may indicate widespread use of the medication rather than a specific safety concern for Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)).
Other Dog Breeds
Retriever - Labrador
90,806 reports · 360.0% death rate
Crossbred Canine/dog
68,210 reports · 320.0% death rate
Dog (unknown)
47,381 reports · 870.0% death rate
Retriever - Golden
34,475 reports · 370.0% death rate
Shepherd Dog - German
31,142 reports · 430.0% death rate
Chihuahua
30,657 reports · 420.0% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne))? ▼
There are 2,087 adverse event reports involving Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) in the FDA database, with 91 reports involving death (440.0% death rate). Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) ranks #79 by report volume.
What are the most common adverse reactions reported for Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne))? ▼
The most commonly reported adverse reactions for Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) are Vomiting (521 reports), Lethargy (see also Central nervous system depression in 'Neurological') (241 reports), Emesis (201 reports), Lack of efficacy (ectoparasite) - flea (196 reports), Diarrhoea (190 reports).
What drugs are most frequently associated with Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) adverse events? ▼
The drugs most frequently referenced in Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) adverse event reports are Milbemycin Oxime + Spinosad (391 reports), Spinosad (222 reports), Afoxolaner (152 reports), Ivermectin + Pyrantel As Pamoate Salt (136 reports), Fluralaner Chew Tablets (113 reports).
What is the average age of Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) in adverse event reports? ▼
The average age of Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) at the time of adverse event reports is 6.7 years, with an average weight of 5.0 kg (11.0 lbs).
Does a high number of adverse event reports mean Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Guides & Resources
Understanding Adverse Events
What FDA reports are and how they are collected
Breed-Specific Risks
Why some breeds appear in more adverse event reports
Pet Medication Safety
Evaluating medication risks using FDA data
Most Reported Medications
Drugs that appear most in adverse event reports
How FDA CVM Tracks Events
The reporting process and database limitations
Related Data Sources
Data Sources & Methodology
Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne)) ranks #79 by total report volume. Death rate (440.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.
Read our methodology — how this data is sourced, computed, and verified.
Related
Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial