Dog /
Papillon - Spaniel - Continental Toy (with erect ears or with dropped ears (Phaléne))
2,087 adverse event reports submitted to the FDA
Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,087
Total Reports
91
Deaths Reported
440.0%
Death Rate
6.7 yr
Avg Age at Report
Average weight at time of report: 5.0 kg (11.0 lbs)
Top Reported Reactions
Vomiting 521
Lethargy (see also Central nervous system depression in 'Neurological') 241
Emesis 201
Lack of efficacy (ectoparasite) - flea 196
Diarrhoea 190
Anorexia 108
Seizure NOS 107
Lack of efficacy - NOS 100
Behavioural disorder NOS 77
Pruritus 70
Other abnormal test result NOS 62
Decreased appetite 58
Lack of efficacy (endoparasite) - hookworm 54
Panting 53
Not eating 51
Most Referenced Drugs
Milbemycin Oxime + Spinosad 391
Spinosad 222
Afoxolaner 152
Ivermectin + Pyrantel As Pamoate Salt 136
Fluralaner Chew Tablets 113
Pyrantel Pamoate;Sarolaner 77
Selamectin 66
Imidacloprid + Moxidectin 60
Moxidectin 55
Oclacitinib Maleate 51
Fluralaner 13.64% 12-Week Chew 50
Milbemycin Oxime + Praziquantel 46
Maropitant Citrate 43
Sarolaner 42
Ivermectin, Pyrantel 37
Outcome Breakdown
Recovered/Normal
782 (41.1%)
Outcome Unknown
557 (29.3%)
Ongoing
385 (20.3%)
Recovered with Sequela
86 (4.5%)
Died
57 (3.0%)
Euthanized
34 (1.8%)
Gender Distribution
Female 1,025 (49.1%)
Male 1,012 (48.5%)
Unknown 48 (2.3%)
Mixed 2 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 107 | |
| 2011 | 126 | |
| 2012 | 175 | |
| 2013 | 195 | |
| 2014 | 164 | |
| 2015 | 184 | |
| 2016 | 176 | |
| 2017 | 138 | |
| 2018 | 161 | |
| 2019 | 128 | |
| 2020 | 103 | |
| 2021 | 97 | |
| 2022 | 73 | |
| 2023 | 96 | |
| 2024 | 74 | |
| 2025 | 90 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #79 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.