Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
37
Total Reports
1
Deaths Reported
270.0%
Death Rate
4.7 yr
Avg Age at Report
Average weight at time of report: 19.5 kg (43.0 lbs)
Top Reported Reactions
Lethargy (see also Central nervous system depression in 'Neurological') 7
Vomiting 7
Lack of efficacy (endoparasite) - hookworm 3
Emesis 3
Lack of efficacy (endoparasite) - heartworm 3
Not eating 2
Shaking 2
Elevated alanine aminotransferase (ALT) 2
Seizure NOS 2
Digestive tract disorder NOS 2
INEFFECTIVE, HOOKS 2
Behavioural disorder NOS 1
Sleepiness - neurological disorder 1
Leucocytosis NOS 1
Neutrophilia 1
Most Referenced Drugs
Milbemycin Oxime + Spinosad 8
Ivermectin + Pyrantel As Pamoate Salt 5
Milbemycin Oxime + Praziquantel 4
Carprofen 3
Nitenpyram 3
Fluralaner Chew Tablets 2
Afoxolaner 2
Ivermectin 2
Tramadol 2
Sarolaner 2
Pyrantel Pamoate;Sarolaner 2
Bedinvetmab 2
Herbals 1
Lufenuron + Milbemycin Oxime 1
Spinosad 1
Outcome Breakdown
Outcome Unknown
13 (35.1%)
Recovered/Normal
12 (32.4%)
Ongoing
9 (24.3%)
Recovered with Sequela
2 (5.4%)
Euthanized
1 (2.7%)
Gender Distribution
Female 22 (59.5%)
Male 15 (40.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 1 | |
| 2012 | 2 | |
| 2013 | 2 | |
| 2014 | 1 | |
| 2015 | 6 | |
| 2016 | 2 | |
| 2017 | 1 | |
| 2018 | 9 | |
| 2019 | 5 | |
| 2020 | 2 | |
| 2022 | 1 | |
| 2023 | 2 | |
| 2024 | 2 | |
| 2025 | 1 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #299 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.