Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
168
Total Reports
8
Deaths Reported
480.0%
Death Rate
5.3 yr
Avg Age at Report
Average weight at time of report: 24.9 kg (54.9 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - hookworm 36
Vomiting 29
Lethargy (see also Central nervous system depression in 'Neurological') 14
Lack of efficacy (endoparasite) - heartworm 14
Diarrhoea 13
INEFFECTIVE, HOOKS 10
Lack of efficacy (endoparasite) - whipworm 7
Depression 6
Bloody diarrhoea 5
Anorexia 5
Death by euthanasia 5
Seizure NOS 5
Other abnormal test result NOS 5
Panting 5
Overdose 5
Most Referenced Drugs
Milbemycin Oxime + Spinosad 23
Pyrantel Pamoate;Sarolaner 23
Milbemycin Oxime + Praziquantel 22
Ivermectin + Pyrantel As Pamoate Salt 15
Moxidectin 12
Melarsomine Dihydrochloride 8
Ivermectin 8
Imidacloprid + Moxidectin 8
Spinosad 7
Fenbendazole 7
Afoxolaner 7
Trilostane 6
Sarolaner 6
Carprofen 5
Maropitant Citrate 5
Outcome Breakdown
Outcome Unknown
59 (39.3%)
Ongoing
50 (33.3%)
Recovered/Normal
32 (21.3%)
Died
4 (2.7%)
Euthanized
4 (2.7%)
Recovered with Sequela
1 (0.7%)
Gender Distribution
Female 87 (51.8%)
Male 72 (42.9%)
Unknown 8 (4.8%)
Mixed 1 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 10 | |
| 2011 | 5 | |
| 2012 | 7 | |
| 2013 | 10 | |
| 2014 | 6 | |
| 2015 | 4 | |
| 2016 | 17 | |
| 2017 | 11 | |
| 2018 | 4 | |
| 2019 | 7 | |
| 2020 | 10 | |
| 2021 | 17 | |
| 2022 | 13 | |
| 2023 | 16 | |
| 2024 | 18 | |
| 2025 | 13 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #195 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.