Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
7,250
Total Reports
254
Deaths Reported
350.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 9.9 kg (21.8 lbs)
Top Reported Reactions
Vomiting 1,815
Emesis 1,119
Lack of efficacy (ectoparasite) - flea 662
Lethargy (see also Central nervous system depression in 'Neurological') 650
Diarrhoea 552
Lack of efficacy - NOS 361
Anorexia 317
Seizure NOS 301
Lack of efficacy (endoparasite) - hookworm 296
Depression 278
Behavioural disorder NOS 173
Ataxia 163
Pruritus 151
Not eating 147
Elevated alanine aminotransferase (ALT) 143
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,945
Spinosad 1,248
Pyrantel Pamoate;Sarolaner 640
Moxidectin 385
Milbemycin Oxime + Praziquantel 255
Oclacitinib Maleate 242
Sarolaner 220
Selamectin 190
Carprofen 175
Fluralaner Chew Tablets 161
Ivermectin, Pyrantel 155
Lotilaner 129
Bedinvetmab 123
Fluralaner 13.64% 12-Week Chew 121
Maropitant Citrate 116
Outcome Breakdown
Recovered/Normal
2,603 (44.0%)
Ongoing
1,539 (26.0%)
Outcome Unknown
1,339 (22.6%)
Recovered with Sequela
177 (3.0%)
Died
163 (2.8%)
Euthanized
95 (1.6%)
Gender Distribution
Male 3,597 (49.6%)
Female 3,436 (47.4%)
Unknown 192 (2.6%)
Mixed 25 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 706 | |
| 2011 | 876 | |
| 2012 | 792 | |
| 2013 | 581 | |
| 2014 | 493 | |
| 2015 | 381 | |
| 2016 | 353 | |
| 2017 | 303 | |
| 2018 | 283 | |
| 2019 | 293 | |
| 2020 | 341 | |
| 2021 | 291 | |
| 2022 | 314 | |
| 2023 | 390 | |
| 2024 | 491 | |
| 2025 | 362 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #31 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.