Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,080
Total Reports
271
Deaths Reported
660.0%
Death Rate
6.8 yr
Avg Age at Report
Average weight at time of report: 13.1 kg (28.9 lbs)
Top Reported Reactions
Vomiting 924
Diarrhoea 379
Emesis 377
Lethargy (see also Central nervous system depression in 'Neurological') 344
Lack of efficacy - NOS 226
Lack of efficacy (endoparasite) - hookworm 194
Anorexia 180
Lack of efficacy (ectoparasite) - flea 175
Seizure NOS 171
INEFFECTIVE, HEARTWORM LARVAE 158
Death by euthanasia 153
Other abnormal test result NOS 147
Digestive tract disorder NOS 136
Elevated alanine aminotransferase (ALT) 122
Elevated blood urea nitrogen (BUN) 120
Most Referenced Drugs
Milbemycin Oxime + Spinosad 718
Ivermectin + Pyrantel As Pamoate Salt 324
Afoxolaner 261
Spinosad 206
Fluralaner Chew Tablets 183
Milbemycin Oxime + Praziquantel 166
Pyrantel Pamoate;Sarolaner 162
Carprofen 144
Milbemycin Oxime 109
Oclacitinib Maleate 104
Bedinvetmab 101
Moxidectin 100
Imidacloprid + Moxidectin 96
Trilostane 93
Selamectin 89
Outcome Breakdown
Recovered/Normal
1,371 (37.3%)
Outcome Unknown
1,118 (30.4%)
Ongoing
746 (20.3%)
Recovered with Sequela
168 (4.6%)
Euthanized
139 (3.8%)
Died
132 (3.6%)
Gender Distribution
Female 2,005 (49.1%)
Male 1,958 (48.0%)
Unknown 103 (2.5%)
Mixed 14 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 231 | |
| 2011 | 271 | |
| 2012 | 384 | |
| 2013 | 373 | |
| 2014 | 378 | |
| 2015 | 335 | |
| 2016 | 288 | |
| 2017 | 325 | |
| 2018 | 263 | |
| 2019 | 179 | |
| 2020 | 213 | |
| 2021 | 176 | |
| 2022 | 146 | |
| 2023 | 161 | |
| 2024 | 222 | |
| 2025 | 135 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #50 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.