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Breed profile · FDA CVM July 2026 extract

Sheepdog - Shetland adverse-event record

Adverse-event filings for Sheepdog - Shetland (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#50 of 510
by report volume (all breeds)
4,159
FDA CVM reports on file
6.7%
death-coded share of reports
#94 of 275
by death-coded share (≥50 reports)

How the 4,159 reports break down

By recorded gender -- every report on file for Sheepdog - Shetland, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 226 169.5 113 56.5 0 2019 2020 2021 2022 2023 2024 2025 2026 Reports filed Death-coded reports
Annual report volume for Sheepdog - Shetland drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Sheepdog - Shetland ranks #50 of 510 by total reports (4,159) and #94 of 275 by death-coded share (6.7%). National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#50
This breed, reports of 510
#94
This breed, death share of 275

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Sheepdog - Shetland has 4,159 reports now versus 4,120 in that prior snapshot: 39 more (0.9%).

Report change
+39
Death-coded reports
+3
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Sheepdog - Shetland changes

Total Reports

4,159

Highest-reported breed

Deaths Reported

277

of 4,159 reports

Death-coded share of reports

6.7%

Above-median death-coded share

Avg Age at Report

6.8 yr

13.1 kg avg weight

Breed Safety Scorecard

D (42/100)

A weighted composite across 4 of 4 dimensions, each benchmarked against every tracked breed with at least 200 reports (n=185). Dimensions with insufficient data drop out and their weight redistributes to the rest, so a missing input never silently deflates the score.

Death rate F
6.7%

Share of reports coded as a fatality

Euthanasia rate F
3.4%

Share of reports resulting in euthanasia

Full recovery rate B-
33.5%

Share of reports coded "Recovered/Normal"

5-year trend C
+2%

Change in annual report volume over the last 5 complete years

Death-Coded Outcome Share

Sheepdog - Shetland death-coded reports 6.7%
Cross-breed median

6.7% of 4,159 sheepdog - shetland reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Where Sheepdog - Shetland's death-coded share sits among indexed breeds

Death-coded share of FDA CVM reports, breeds with ≥50 reports (July 2026 extract)

7% 66th percentile Higher share than 66% of 275 indexed breeds

5%–10%: 1 indexed breeds (0%). This entry sits in this band. 20%–25%: 2 indexed breeds (1%). Above this entry. 25%–30%: 3 indexed breeds (1%). Above this entry. 30%–35%: 4 indexed breeds (1%). Above this entry. 35%–40%: 5 indexed breeds (2%). Above this entry. 40%–45%: 6 indexed breeds (2%). Above this entry. 45%–50%: 3 indexed breeds (1%). Above this entry. 50%–55%: 7 indexed breeds (3%). Above this entry. 55%–60%: 7 indexed breeds (3%). Above this entry. 60%–65%: 21 indexed breeds (8%). Above this entry. 65%–70%: 11 indexed breeds (4%). Above this entry. 70%–75%: 15 indexed breeds (5%). Above this entry. 75%–80%: 13 indexed breeds (5%). Above this entry. 80%–85%: 11 indexed breeds (4%). Above this entry. 85%–90%: 12 indexed breeds (4%). Above this entry. 90%–95%: 12 indexed breeds (4%). Above this entry. 95%–100%: 142 indexed breeds (52%). Above this entry. Sheepdog - Shetland 5% 100% every breed with ≥50 FDA reports, bucketed by value

Each bar is a band; taller bars hold more indexed breeds. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count, share, and where it sits relative to this entry.

Source FDA Center for Veterinary Medicine, openFDA adverse event extract (PlainBreed) · July 2026 extract

This histogram uses the same ≥50-report cohort as the highest death-coded share ranking. A higher share means more of this breed's reported events were death-coded, not a mortality rate for living animals.

Sheepdog - Shetland among report-volume vs. death-rate peers

Every breed shown has at least 50 filed reports. Volume reflects how often a breed is reported, not how common it is; death rate is the share of a breed's own reports coded as a death outcome.

Source: FDA openFDA Animal & Veterinary Adverse Events database 2×2 strategic matrix plotting 30 entities by Total Reports (X) and Death Rate (%) (Y), with a crosshair dividing the plot into four quadrants. High volume, high death rateLow volume, high death rateHigh volume, low death rateLow volume, low death rate 020,00040,00060,00080,000100,000 0%5%10%15% Total Reports Death Rate (%) Sheepdog - Shetland vs. all breeds, report volume and death-coded share Retriever - Labrador-93675, 3.7%Crossbred Canine/dog-70591, 3.2%Domestic Shorthair-65226, 7.2%Dog (unknown)-48820, 8.8%Retriever - Golden-35980, 3.7%Shepherd Dog - German-32220, 4.4%Chihuahua-31521, 4.2%Terrier - Yorkshire-24924, 3.7%Shih Tzu-24405, 3.6%Boxer (German Boxer)-19405, 4.4%Beagle-17970, 3.6%Pit Bull-17865, 3.1%Shepherd Dog - Australian-16274, 3.7%Terrier (unspecified)-14058, 3.1%Maltese-13940, 3.2%Dachshund (unspecified)-13512, 4.6%Cat (unknown)-13248, 9.3%Terrier - Jack Russell-10423, 3.7%Collie - Border-10130, 4.3%Siberian Husky-9811, 4.5%Domestic Longhair-9615, 7%Pug-9224, 5.2%Spitz - German Pomeranian-9086, 4.9%Terrier - Bull - American Pit-8769, 4.7%Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)-7871, 3.6%Terrier - Boston-7737, 4.5%Spaniel - Cocker American-7640, 4%Domestic (unspecified)-7576, 13.4%Poodle (unspecified)-7534, 3.4%Schnauzer - Miniature-7513, 4.4%
Source: FDA openFDA Animal & Veterinary Adverse Events database
Average weight at time of report: 13.1 kg (28.9 lbs)

Top Reported Reactions

Vomiting 935
Diarrhoea 386
Emesis 377
Lethargy (see also Central nervous system depression in 'Neurological') 344
Lack of efficacy - NOS 227
Lack of efficacy (endoparasite) - hookworm 198
Anorexia 180
Lack of efficacy (ectoparasite) - flea 178
Seizure NOS 175
INEFFECTIVE, HEARTWORM LARVAE 158
Death by euthanasia 156
Other abnormal test result NOS 150
Digestive tract disorder NOS 136
Elevated alanine aminotransferase (ALT) 124
Elevated blood urea nitrogen (BUN) 123

Most Referenced Drugs

Milbemycin Oxime + Spinosad 718
Ivermectin + Pyrantel As Pamoate Salt 330
Afoxolaner 266
Spinosad 206
Fluralaner Chew Tablets 183
Milbemycin Oxime + Praziquantel 173
Pyrantel Pamoate;Sarolaner 173
Carprofen 148
Bedinvetmab 117
Milbemycin Oxime 111
Oclacitinib Maleate 110
Moxidectin 102
Imidacloprid + Moxidectin 96
Trilostane 93
Fluralaner 13.64% 12-Week Chew 91

Outcome Breakdown

Recovered/Normal
1,394 (37.2%)
Outcome Unknown
1,133 (30.2%)
Ongoing
780 (20.8%)
Recovered with Sequela
168 (4.5%)
Euthanized
141 (3.8%)
Died
136 (3.6%)

Gender Distribution

Female 2,045 (49.2%)
Male 1,996 (48.0%)
Unknown 104 (2.5%)
Mixed 14 (0.3%)

Reports by Year

Year Reports Trend
2010 231
2011 271
2012 384
2013 373
2014 378
2015 335
2016 288
2017 325
2018 263
2019 179
2020 213
2021 176
2022 146
2023 161
2024 226
2025 180
2026 30

Sheepdog - Shetland: high death-coded share in the FDA CVM extract

Signature read: 4,159 reports place Sheepdog - Shetland in the upper third of breed filing volume (#50 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Sheepdog - Shetland sits at #50 of 510 by report volume among all breeds and #44 of 298 among dog breeds, with 4,159 reports and 277 (6.7%) death-coded. On death-coded share among breeds with ≥50 reports, it ranks #94 of 275. Mean age at report: 6.8 years, average weight 13.1 kg (28.9 lbs).

Top reported signs: Vomiting (935), Diarrhoea (386), Emesis (377). Most-referenced drug: Milbemycin Oxime + Spinosad (718 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (330) and Afoxolaner (266).

Outcome coding on 3,752 status-recorded reports is dominated by Recovered/Normal (37.2%). Annual submissions ranged 30-2,026 across 17 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Poodle - Toy
4,180 reports · 4.0% death-coded
Dachshund - Miniature
4,234 reports · 4.6% death-coded
Havanese
3,977 reports · 2.1% death-coded
Terrier - West Highland White
4,343 reports · 4.9% death-coded
Deutsche Dogge, Great Dane
4,353 reports · 6.0% death-coded
Pointing Dog - German Short-haired
3,953 reports · 3.3% death-coded

Nationwide breeds with similar profiles

High-volume peer sets for Sheepdog - Shetland drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

Similar death-coded share

Nearest other-species breeds with ≥50 reports (6.7% death-coded here).

Domestic Longhair 7.0% · Cat Crossbred Feline/cat 6.3% · Cat Snowshoe 7.0% · Cat Warmblood (unspecified) 7.0% · Horse

Similar average weight

Nearest other-species breeds by reported average weight (13.1 kg here).

Wild cat 14.5 kg · Cat Monkey (unspecified) 11.6 kg · Monkey Primate (other) 10.1 kg · Primate Nigerian Dwarf 7.5 kg · Goat

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Sheepdog - Shetland? ▼
There are 4,159 adverse event reports involving Sheepdog - Shetland in the FDA database, of which 277 were death-coded (6.7% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Sheepdog - Shetland ranks #50 of 510 by report volume among all breeds PlainBreed indexes (#44 of 298 among dog breeds).
Where does Sheepdog - Shetland sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Sheepdog - Shetland is #50 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #44 of 298. Among breeds with at least 50 reports, its death-coded share ranks #94 of 275 (same cohort as highest-death-rate). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Sheepdog - Shetland? ▼
The most commonly reported adverse reactions for Sheepdog - Shetland are Vomiting (935 reports), Diarrhoea (386 reports), Emesis (377 reports), Lethargy (see also Central nervous system depression in 'Neurological') (344 reports), Lack of efficacy - NOS (227 reports).
What drugs are most frequently associated with Sheepdog - Shetland adverse events? ▼
The drugs most frequently referenced in Sheepdog - Shetland adverse event reports are Milbemycin Oxime + Spinosad (718 reports), Ivermectin + Pyrantel As Pamoate Salt (330 reports), Afoxolaner (266 reports), Spinosad (206 reports), Fluralaner Chew Tablets (183 reports).
What is the average age of Sheepdog - Shetland in adverse event reports? ▼
The average age of Sheepdog - Shetland at the time of adverse event reports is 6.8 years, with an average weight of 13.1 kg (28.9 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Sheepdog - Shetland (Dog), extract as of July 2026 extract. 4,159 reports · 277 death-coded (6.7% of reports, not a mortality rate) · #50 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →