Total Reports
4,080
FDA CVM filings
Dog /
FDA CVM · 2025 release 4,080 reports on file
Sheepdog - Shetland - FDA Adverse Event Profile
Adverse-event records for Sheepdog - Shetland (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Sheepdog - Shetland ranks #50 by report volume among dog breeds - 271 of 4,080 reports (6.6%) recorded a death outcome.
- #50
- most-reported dog breed
- 6.6%
- death-coded report share
- 924
- Vomiting - top reaction
- 6.8 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
271
of 4,080 reports
Death Rate
6.6%
death-coded share
Avg Age at Report
6.8 yr
13.1 kg avg weight
Death-Coded Outcome Share
Sheepdog - Shetland death-coded reports 6.6%
Cross-breed median
6.6% of 4,080 sheepdog - shetland reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 13.1 kg (28.9 lbs)
Top Reported Reactions
Vomiting 924
Diarrhoea 379
Emesis 377
Lethargy (see also Central nervous system depression in 'Neurological') 344
Lack of efficacy - NOS 226
Lack of efficacy (endoparasite) - hookworm 194
Anorexia 180
Lack of efficacy (ectoparasite) - flea 175
Seizure NOS 171
INEFFECTIVE, HEARTWORM LARVAE 158
Death by euthanasia 153
Other abnormal test result NOS 147
Digestive tract disorder NOS 136
Elevated alanine aminotransferase (ALT) 122
Elevated blood urea nitrogen (BUN) 120
Most Referenced Drugs
Milbemycin Oxime + Spinosad 718
Ivermectin + Pyrantel As Pamoate Salt 324
Afoxolaner 261
Spinosad 206
Fluralaner Chew Tablets 183
Milbemycin Oxime + Praziquantel 166
Pyrantel Pamoate;Sarolaner 162
Carprofen 144
Milbemycin Oxime 109
Oclacitinib Maleate 104
Bedinvetmab 101
Moxidectin 100
Imidacloprid + Moxidectin 96
Trilostane 93
Selamectin 89
Outcome Breakdown
Recovered/Normal
1,371 (37.3%)
Outcome Unknown
1,118 (30.4%)
Ongoing
746 (20.3%)
Recovered with Sequela
168 (4.6%)
Euthanized
139 (3.8%)
Died
132 (3.6%)
Gender Distribution
Female 2,005 (49.1%)
Male 1,958 (48.0%)
Unknown 103 (2.5%)
Mixed 14 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 231 | |
| 2011 | 271 | |
| 2012 | 384 | |
| 2013 | 373 | |
| 2014 | 378 | |
| 2015 | 335 | |
| 2016 | 288 | |
| 2017 | 325 | |
| 2018 | 263 | |
| 2019 | 179 | |
| 2020 | 213 | |
| 2021 | 176 | |
| 2022 | 146 | |
| 2023 | 161 | |
| 2024 | 222 | |
| 2025 | 135 | |
Sheepdog - Shetland Pet Health Insights
Sheepdog - Shetland accounts for 4,080 FDA adverse event reports, ranking #50 by volume among dog breeds, with 271 reports (6.6%) coded as a death outcome. Mean age at report: 6.8 years, average weight 13.1 kg (28.9 lbs).
Top reported signs: Vomiting (924), Diarrhoea (379), Emesis (377). Most-referenced drug: Milbemycin Oxime + Spinosad (718 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (324) and Afoxolaner (261).
Outcome coding on 3,674 status-recorded reports is dominated by Recovered/Normal (37.3%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Poodle - Toy
4,084 reports · 4.0% death rate
Dachshund - Miniature
4,095 reports · 4.6% death rate
Deutsche Dogge, Great Dane
4,227 reports · 6.0% death rate
Terrier - West Highland White
4,266 reports · 4.9% death rate
Great Pyrenees
4,292 reports · 3.8% death rate
Hound - Basset
3,859 reports · 4.0% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Sheepdog - Shetland? ▼
There are 4,080 adverse event reports involving Sheepdog - Shetland in the FDA database, with 271 reports involving death (6.6% death rate). Sheepdog - Shetland ranks #50 by report volume.
What are the most common adverse reactions reported for Sheepdog - Shetland? ▼
The most commonly reported adverse reactions for Sheepdog - Shetland are Vomiting (924 reports), Diarrhoea (379 reports), Emesis (377 reports), Lethargy (see also Central nervous system depression in 'Neurological') (344 reports), Lack of efficacy - NOS (226 reports).
What drugs are most frequently associated with Sheepdog - Shetland adverse events? ▼
The drugs most frequently referenced in Sheepdog - Shetland adverse event reports are Milbemycin Oxime + Spinosad (718 reports), Ivermectin + Pyrantel As Pamoate Salt (324 reports), Afoxolaner (261 reports), Spinosad (206 reports), Fluralaner Chew Tablets (183 reports).
What is the average age of Sheepdog - Shetland in adverse event reports? ▼
The average age of Sheepdog - Shetland at the time of adverse event reports is 6.8 years, with an average weight of 13.1 kg (28.9 lbs).
Does a high number of adverse event reports mean Sheepdog - Shetland is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Sheepdog - Shetland safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.