Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,266
Total Reports
211
Deaths Reported
490.0%
Death Rate
7.4 yr
Avg Age at Report
Average weight at time of report: 8.7 kg (19.2 lbs)
Top Reported Reactions
Vomiting 1,015
Emesis 502
Lethargy (see also Central nervous system depression in 'Neurological') 437
Diarrhoea 370
Lack of efficacy - NOS 262
Lack of efficacy (ectoparasite) - flea 214
Anorexia 207
Other abnormal test result NOS 160
Lack of efficacy (endoparasite) - hookworm 154
Deafness 133
Death by euthanasia 127
Behavioural disorder NOS 121
Digestive tract disorder NOS 116
Elevated serum alkaline phosphatase (SAP) 116
Polydipsia 115
Most Referenced Drugs
Milbemycin Oxime + Spinosad 832
Oclacitinib Maleate 395
Spinosad 322
Ivermectin + Pyrantel As Pamoate Salt 270
Cyclosporine 220
Afoxolaner 209
Fluralaner Chew Tablets 158
Cyclosporine A 151
Pyrantel Pamoate;Sarolaner 146
Moxidectin 110
Prednisone 97
Trilostane 92
Milbemycin Oxime + Praziquantel 84
Sarolaner 81
Carprofen 79
Outcome Breakdown
Recovered/Normal
1,519 (39.8%)
Outcome Unknown
987 (25.9%)
Ongoing
923 (24.2%)
Recovered with Sequela
177 (4.6%)
Euthanized
111 (2.9%)
Died
100 (2.6%)
Gender Distribution
Male 2,224 (52.1%)
Female 1,938 (45.4%)
Unknown 92 (2.2%)
Mixed 12 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 226 | |
| 2011 | 291 | |
| 2012 | 416 | |
| 2013 | 401 | |
| 2014 | 406 | |
| 2015 | 374 | |
| 2016 | 351 | |
| 2017 | 355 | |
| 2018 | 273 | |
| 2019 | 223 | |
| 2020 | 199 | |
| 2021 | 176 | |
| 2022 | 163 | |
| 2023 | 133 | |
| 2024 | 171 | |
| 2025 | 108 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #46 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.