Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,020
Total Reports
34
Deaths Reported
330.0%
Death Rate
4.0 yr
Avg Age at Report
Average weight at time of report: 38.6 kg (85.1 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 174
INEFFECTIVE, HEARTWORM LARVAE 154
Vomiting 116
Lack of efficacy - NOS 77
Lethargy (see also Central nervous system depression in 'Neurological') 54
Lack of efficacy (endoparasite) - hookworm 51
Emesis 50
Lack of efficacy (ectoparasite) - flea 40
Cardiac disorder NOS 38
Diarrhoea 37
Other abnormal test result NOS 31
Lack of efficacy (endoparasite) - whipworm 30
Digestive tract disorder NOS 28
Weight loss 22
Weight gain 21
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 207
Milbemycin Oxime + Spinosad 157
Moxidectin 86
Milbemycin Oxime + Praziquantel 55
Pyrantel Pamoate;Sarolaner 53
Fluralaner Chew Tablets 42
Afoxolaner 40
Spinosad 31
Oclacitinib Maleate 31
Ivermectin, Pyrantel 30
Carprofen 26
Milbemycin Oxime 26
Imidacloprid + Moxidectin 24
Ivermectin 21
Milbemycin 20
Outcome Breakdown
Outcome Unknown
342 (36.7%)
Ongoing
269 (28.8%)
Recovered/Normal
203 (21.8%)
Recovered with Sequela
85 (9.1%)
Died
21 (2.3%)
Euthanized
13 (1.4%)
Gender Distribution
Male 518 (50.8%)
Female 483 (47.4%)
Unknown 11 (1.1%)
Mixed 8 (0.8%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 46 | |
| 2011 | 55 | |
| 2012 | 60 | |
| 2013 | 57 | |
| 2014 | 58 | |
| 2015 | 70 | |
| 2016 | 78 | |
| 2017 | 81 | |
| 2018 | 70 | |
| 2019 | 79 | |
| 2020 | 63 | |
| 2021 | 68 | |
| 2022 | 77 | |
| 2023 | 62 | |
| 2024 | 60 | |
| 2025 | 36 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #109 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.