Total Reports
357
FDA CVM filings
Dog /
FDA CVM · 2025 release 357 reports on file
Collie - Rough-haired - FDA Adverse Event Profile
Adverse-event records for Collie - Rough-haired (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Collie - Rough-haired is #156 by FDA report volume; 5.0% of its 357 reports (18) were death-coded.
- #156
- most-reported dog breed
- 5.0%
- death-coded report share
- 78
- Vomiting - top reaction
- 5.3 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
18
of 357 reports
Death Rate
5.0%
death-coded share
Avg Age at Report
5.3 yr
28.2 kg avg weight
Death-Coded Outcome Share
Collie - Rough-haired death-coded reports 5.0%
Cross-breed median
5.0% of 357 collie - rough-haired reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 28.2 kg (62.2 lbs)
Top Reported Reactions
Vomiting 78
Lethargy (see also Central nervous system depression in 'Neurological') 41
Diarrhoea 32
Emesis 24
Seizure NOS 24
Lack of efficacy - NOS 19
Ataxia 18
Anorexia 16
Most Referenced Drugs
Milbemycin Oxime + Spinosad 64
Milbemycin Oxime + Praziquantel 53
Pyrantel Pamoate;Sarolaner 25
Bedinvetmab 23
Fluralaner 13.64% 12-Week Chew 21
Lotilaner 20
Milbemycin Oxime 19
Trilostane 17
Outcome Breakdown
Recovered/Normal
129 (35.9%)
Ongoing
112 (31.2%)
Outcome Unknown
92 (25.6%)
Died
12 (3.3%)
Recovered with Sequela
8 (2.2%)
Euthanized
6 (1.7%)
Gender Distribution
Male 182 (51.0%)
Female 163 (45.7%)
Unknown 10 (2.8%)
Mixed 2 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 2 | |
| 2012 | 21 | |
| 2013 | 23 | |
| 2014 | 19 | |
| 2015 | 19 | |
| 2016 | 21 | |
| 2017 | 23 | |
| 2018 | 29 | |
| 2019 | 23 | |
| 2020 | 28 | |
| 2021 | 30 | |
| 2022 | 28 | |
| 2023 | 23 | |
| 2024 | 45 | |
| 2025 | 23 | |
Collie - Rough-haired Pet Health Insights
Collie - Rough-haired accounts for 357 FDA adverse event reports, ranking #156 by volume among dog breeds, with 18 reports (5.0%) coded as a death outcome. Mean age at report: 5.3 years, average weight 28.2 kg (62.2 lbs).
Top reported signs: Vomiting (78), Lethargy (see also Central nervous system depression in 'Neurological') (41), Diarrhoea (32). Most-referenced drug: Milbemycin Oxime + Spinosad (64 reports), followed by Milbemycin Oxime + Praziquantel (53) and Pyrantel Pamoate;Sarolaner (25).
Outcome coding on 359 status-recorded reports is dominated by Recovered/Normal (35.9%). Annual submissions ranged 2,011-2,025 across 15 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Collie - Rough-haired? ▼
There are 357 adverse event reports involving Collie - Rough-haired in the FDA database, with 18 reports involving death (5.0% death rate). Collie - Rough-haired ranks #156 by report volume.
What are the most common adverse reactions reported for Collie - Rough-haired? ▼
The most commonly reported adverse reactions for Collie - Rough-haired are Vomiting (78 reports), Lethargy (see also Central nervous system depression in 'Neurological') (41 reports), Diarrhoea (32 reports), Emesis (24 reports), Seizure NOS (24 reports).
What drugs are most frequently associated with Collie - Rough-haired adverse events? ▼
The drugs most frequently referenced in Collie - Rough-haired adverse event reports are Milbemycin Oxime + Spinosad (64 reports), Milbemycin Oxime + Praziquantel (53 reports), Pyrantel Pamoate;Sarolaner (25 reports), Bedinvetmab (23 reports), Fluralaner 13.64% 12-Week Chew (21 reports).
What is the average age of Collie - Rough-haired in adverse event reports? ▼
The average age of Collie - Rough-haired at the time of adverse event reports is 5.3 years, with an average weight of 28.2 kg (62.2 lbs).
Does a high number of adverse event reports mean Collie - Rough-haired is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Collie - Rough-haired safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.