Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
357
Total Reports
18
Deaths Reported
500.0%
Death Rate
5.3 yr
Avg Age at Report
Average weight at time of report: 28.2 kg (62.2 lbs)
Top Reported Reactions
Vomiting 78
Lethargy (see also Central nervous system depression in 'Neurological') 41
Diarrhoea 32
Emesis 24
Seizure NOS 24
Lack of efficacy - NOS 19
Ataxia 18
Anorexia 16
Panting 15
Emesis (multiple) 13
Lack of efficacy (ectoparasite) - flea 12
Behavioural disorder NOS 11
Other abnormal test result NOS 11
Not eating 11
Lack of efficacy (bacteria) - Borrelia 11
Most Referenced Drugs
Milbemycin Oxime + Spinosad 64
Milbemycin Oxime + Praziquantel 53
Pyrantel Pamoate;Sarolaner 25
Bedinvetmab 23
Fluralaner 13.64% 12-Week Chew 21
Lotilaner 20
Milbemycin Oxime 19
Trilostane 17
Sarolaner 17
Carprofen 16
Maropitant Citrate 13
Afoxolaner 13
Lufenuron + Milbemycin Oxime 11
Oclacitinib Maleate 11
Gabapentin 11
Outcome Breakdown
Recovered/Normal
129 (35.9%)
Ongoing
112 (31.2%)
Outcome Unknown
92 (25.6%)
Died
12 (3.3%)
Recovered with Sequela
8 (2.2%)
Euthanized
6 (1.7%)
Gender Distribution
Male 182 (51.0%)
Female 163 (45.7%)
Unknown 10 (2.8%)
Mixed 2 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 2 | |
| 2012 | 21 | |
| 2013 | 23 | |
| 2014 | 19 | |
| 2015 | 19 | |
| 2016 | 21 | |
| 2017 | 23 | |
| 2018 | 29 | |
| 2019 | 23 | |
| 2020 | 28 | |
| 2021 | 30 | |
| 2022 | 28 | |
| 2023 | 23 | |
| 2024 | 45 | |
| 2025 | 23 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #156 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.