Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
615
Total Reports
31
Deaths Reported
500.0%
Death Rate
6.7 yr
Avg Age at Report
Average weight at time of report: 7.1 kg (15.7 lbs)
Top Reported Reactions
Vomiting 158
Lethargy (see also Central nervous system depression in 'Neurological') 60
Diarrhoea 55
Emesis 54
Lack of efficacy - NOS 42
Other abnormal test result NOS 27
Seizure NOS 27
Ataxia 24
Anorexia 23
Lack of efficacy (ectoparasite) - flea 23
Lack of efficacy (endoparasite) - hookworm 23
Decreased appetite 22
Not eating 20
Weight loss 17
Elevated serum alkaline phosphatase (SAP) 17
Most Referenced Drugs
Milbemycin Oxime + Spinosad 102
Ivermectin + Pyrantel As Pamoate Salt 48
Afoxolaner 37
Spinosad 35
Fluralaner Chew Tablets 34
Trilostane 32
Oclacitinib Maleate 32
Moxidectin 27
Fluralaner 13.64% 12-Week Chew 21
Pimobendan 20
Pyrantel Pamoate;Sarolaner 20
Selamectin 19
Carprofen 16
Maropitant Citrate 15
Insulin Injectable Vial 15
Outcome Breakdown
Recovered/Normal
211 (37.0%)
Outcome Unknown
161 (28.2%)
Ongoing
146 (25.6%)
Recovered with Sequela
22 (3.9%)
Euthanized
17 (3.0%)
Died
14 (2.5%)
Gender Distribution
Female 306 (49.8%)
Male 297 (48.3%)
Unknown 9 (1.5%)
Mixed 3 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 18 | |
| 2011 | 34 | |
| 2012 | 47 | |
| 2013 | 42 | |
| 2014 | 54 | |
| 2015 | 51 | |
| 2016 | 46 | |
| 2017 | 45 | |
| 2018 | 47 | |
| 2019 | 41 | |
| 2020 | 29 | |
| 2021 | 23 | |
| 2022 | 45 | |
| 2023 | 37 | |
| 2024 | 32 | |
| 2025 | 24 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #128 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.