Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,051
Total Reports
31
Deaths Reported
290.0%
Death Rate
5.3 yr
Avg Age at Report
Average weight at time of report: 35.5 kg (78.3 lbs)
Top Reported Reactions
INEFFECTIVE, HEARTWORM LARVAE 166
Lack of efficacy (endoparasite) - heartworm 150
Vomiting 136
Lack of efficacy - NOS 81
Lack of efficacy (endoparasite) - hookworm 73
Diarrhoea 60
Lethargy (see also Central nervous system depression in 'Neurological') 53
Seizure NOS 44
INEFFECTIVE, ASCARIDS NOS 42
Digestive tract disorder NOS 35
Cardiac disorder NOS 35
Anorexia 32
Emesis 28
Lack of efficacy (ectoparasite) - flea 25
Other abnormal test result NOS 23
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 196
Milbemycin Oxime + Spinosad 151
Milbemycin Oxime + Praziquantel 84
Afoxolaner 60
Pyrantel Pamoate;Sarolaner 49
Moxidectin 47
Carprofen 41
Ivermectin, Pyrantel 35
Fluralaner Chew Tablets 35
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 29
Milbemycin 28
Bedinvetmab 28
Oclacitinib Maleate 26
Fluralaner 13.64% 12-Week Chew 25
Milbemycin Oxime 23
Outcome Breakdown
Outcome Unknown
356 (38.4%)
Ongoing
258 (27.8%)
Recovered/Normal
208 (22.4%)
Recovered with Sequela
75 (8.1%)
Euthanized
18 (1.9%)
Died
13 (1.4%)
Gender Distribution
Male 568 (54.0%)
Female 468 (44.5%)
Unknown 13 (1.2%)
Mixed 2 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 62 | |
| 2011 | 70 | |
| 2012 | 67 | |
| 2013 | 56 | |
| 2014 | 61 | |
| 2015 | 62 | |
| 2016 | 77 | |
| 2017 | 79 | |
| 2018 | 77 | |
| 2019 | 67 | |
| 2020 | 71 | |
| 2021 | 72 | |
| 2022 | 50 | |
| 2023 | 59 | |
| 2024 | 79 | |
| 2025 | 42 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #108 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.