Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
156
Total Reports
3
Deaths Reported
190.0%
Death Rate
5.2 yr
Avg Age at Report
Average weight at time of report: 21.2 kg (46.7 lbs)
Top Reported Reactions
Vomiting 30
Lack of efficacy (endoparasite) - heartworm 22
Lethargy (see also Central nervous system depression in 'Neurological') 14
Diarrhoea 12
Seizure NOS 12
Inappetence 8
Lack of efficacy (ectoparasite) - flea 7
Pruritus 7
Lack of efficacy (endoparasite) - hookworm 6
Elevated alanine aminotransferase (ALT) 5
Twitching 5
Itching 4
Lack of efficacy - NOS 4
Malaise 4
Panting 4
Most Referenced Drugs
Milbemycin Oxime + Spinosad 16
Afoxolaner 68 Mg Chewable Tablets 14
Ivermectin + Pyrantel As Pamoate Salt 14
Pyrantel Pamoate;Sarolaner 12
Moxidectin 9
Spinosad 8
Selamectin 6
Afoxolaner 6
Afoxolaner 2.27% Chewable Tablet (68 Mg) 6
Afoxolaner 136 Mg Chewable Tablets 6
Milbemycin Oxime + Praziquantel 6
Ivermectin 5
Afoxolaner 28.3 Mg Chewable Tablets 5
Fluralaner Chew Tablets 5
Sarolaner 5
Outcome Breakdown
Outcome Unknown
61 (39.1%)
Recovered/Normal
49 (31.4%)
Ongoing
36 (23.1%)
Recovered with Sequela
7 (4.5%)
Died
2 (1.3%)
Euthanized
1 (0.6%)
Gender Distribution
Female 99 (63.5%)
Male 55 (35.3%)
Unknown 2 (1.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 1 | |
| 2012 | 6 | |
| 2013 | 3 | |
| 2014 | 8 | |
| 2015 | 17 | |
| 2016 | 23 | |
| 2017 | 16 | |
| 2018 | 9 | |
| 2019 | 11 | |
| 2020 | 9 | |
| 2021 | 7 | |
| 2022 | 7 | |
| 2023 | 12 | |
| 2024 | 12 | |
| 2025 | 15 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #200 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.