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Breed profile · FDA CVM July 2026 extract

Tosa adverse-event record

Adverse-event filings for Tosa (Dog) in the FDA Center for Veterinary Medicine openFDA extract. Browse dog breeds, reactions, and outcomes below.

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#477 of 510
by report volume (all breeds)
7
FDA CVM reports on file
14.3%
death-coded share of reports
3
Lack of efficacy - NOS - top reaction

How the 7 reports break down

By recorded gender -- every report on file for Tosa, no filtering.

Annual report volume

Annual adverse-event report trend Yearly FDA CVM adverse-event report counts for this breed. 2 1.5 1 0.5 0 2012 2014 2015 2016 2019 2024 Reports filed Death-coded reports
Annual report volume for Tosa drawn from FDA CVM filings.

Data updated September 2026

The verdict

According to the FDA Center for Veterinary Medicine openFDA adverse-event extract, Tosa ranks #460 of 510 by total reports (7). Death-coded-share rank requires at least 50 reports. National dual: Retriever - Labrador is #1 of 510 by total adverse-event reports (93,675) at death-coded-share rank 195 of 275 breeds with at least 50 reports (3.7%); separately, Atlantic Salmon (Salmo salar) is #1 highest death-coded share at 99.0% (report rank #233).

93,675
Retriever - Labrador reports (#1)
99.0%
Atlantic Salmon (Salmo salar) death share (#1)
#460
This breed, reports of 510

Report volume reflects how common a breed or drug is and how often owners and vets file — not actual risk. Death-coded share ranks are limited to entries with enough reports to be meaningful. The two maps do not agree at #1.

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Tosa has 7 reports now versus 7 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Tosa changes

Total Reports

7

Low report volume

Deaths Reported

1

of 7 reports

Death-coded share of reports

14.3%

14.3% death-coded

Avg Age at Report

5.7 yr

54.7 kg avg weight

Death-Coded Outcome Share

Tosa death-coded reports 14.3%
Cross-breed median

14.3% of 7 tosa reports involved a death outcome.

How to read this number

Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Average weight at time of report: 54.7 kg (120.6 lbs)

Top Reported Reactions

Lack of efficacy - NOS 3
Digestive tract disorder NOS 2
Diarrhoea 2
Lack of efficacy (endoparasite) - hookworm 1
Depression 1

Most Referenced Drugs

Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 1
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 1
Spinosad 1
Rabies Vaccine 1
Oclacitinib Maleate 1

Outcome Breakdown

Ongoing
5 (71.4%)
Died
1 (14.3%)
Outcome Unknown
1 (14.3%)

Gender Distribution

Male 4 (57.1%)
Female 3 (42.9%)

Reports by Year

Year Reports Trend
2012 1
2014 2
2015 1
2016 1
2019 1
2024 1

Tosa: high death-coded share in the FDA CVM extract

Signature read: 7 reports place Tosa in the lower third of breed filing volume (#477 of 510). According to FDA CVM filings indexed on PlainBreed as of July 2026 extract, Tosa sits at #477 of 510 by report volume among all breeds and #289 of 298 among dog breeds, with 7 reports and 1 (14.3%) death-coded. Mean age at report: 5.7 years, average weight 54.7 kg (120.6 lbs).

Top reported signs: Lack of efficacy - NOS (3), Digestive tract disorder NOS (2), Diarrhoea (2). Most-referenced drug: Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg (1 reports), followed by Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg (1) and Spinosad (1).

Outcome coding on 7 status-recorded reports is dominated by Ongoing (71.4%). Annual submissions ranged 1-2,024 across 6 years on file.

Dog Breeds With a Similar Report Volume

Showing 6 of 297 dog breeds in our dataset, ranked by closest report volume.

Buhund - Norwegian
7 reports · 0.0% death-coded
Coolie (German Coolie or Australian Coolie
7 reports · 14.3% death-coded
Hound - Bavarian Mountain
7 reports · 0.0% death-coded
Hound - Finnish
7 reports · 0.0% death-coded
Hound - Italian
7 reports · 0.0% death-coded
Kooikerhondje
7 reports · 0.0% death-coded

Nationwide breeds with similar profiles

Sparse-volume peer sets for Tosa drawn from openFDA outside the Dog family so the neighborhoods are not species containment (the similar-volume list above stays within species).

What to do with this dog

A report does not prove a drug caused the reaction, and popular breeds simply generate more reports.

Frequently Asked Questions

How many FDA adverse event reports involve Tosa? ▼
There are 7 adverse event reports involving Tosa in the FDA database, of which 1 were death-coded (14.3% of those reports). That is a share of REPORTED events, not a mortality rate for the breed: adverse events reach the FDA when something goes wrong, so the denominator is reports, never the population of animals. According to the same FDA CVM extract, Tosa ranks #477 of 510 by report volume among all breeds PlainBreed indexes (#289 of 298 among dog breeds).
Where does Tosa sit among other breeds in PlainBreed's corpus? ▼
According to FDA CVM report volume, Tosa is #477 of 510 breeds indexed on PlainBreed (same ordering as the most-reported-breeds ranking). Inside Dog, it is #289 of 298. It has fewer than 50 reports, so it is outside the death-rate ranking cohort (≥50 reports). These are placement ranks in the reporting corpus, not clinical risk scores.
What are the most common adverse reactions reported for Tosa? ▼
The most commonly reported adverse reactions for Tosa are Lack of efficacy - NOS (3 reports), Digestive tract disorder NOS (2 reports), Diarrhoea (2 reports), Lack of efficacy (endoparasite) - hookworm (1 reports), Depression (1 reports).
What drugs are most frequently associated with Tosa adverse events? ▼
The drugs most frequently referenced in Tosa adverse event reports are Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg (1 reports), Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg (1 reports), Spinosad (1 reports), Rabies Vaccine (1 reports), Oclacitinib Maleate (1 reports).
What is the average age of Tosa in adverse event reports? ▼
The average age of Tosa at the time of adverse event reports is 5.7 years, with an average weight of 54.7 kg (120.6 lbs).

Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how the death-coded share and rankings are computed, or read breed-specific reporting patterns and FDA CVM reporting.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Tosa (Dog), extract as of July 2026 extract. 7 reports · 1 death-coded (14.3% of reports, not a mortality rate) · #477 of 510 by volume.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →