Total Reports
7
FDA CVM filings
Dog /
FDA CVM · 2025 release 7 reports on file
Tosa - FDA Adverse Event Profile
Adverse-event records for Tosa (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Tosa is #459 by FDA report volume; 14.3% of its 7 reports (1) were death-coded.
- #459
- most-reported dog breed
- 14.3%
- death-coded report share
- 3
- Lack of efficacy - NOS - top reaction
- 5.7 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
1
of 7 reports
Death Rate
14.3%
death-coded share
Avg Age at Report
5.7 yr
54.7 kg avg weight
Death-Coded Outcome Share
Tosa death-coded reports 14.3%
Cross-breed median
14.3% of 7 tosa reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 54.7 kg (120.6 lbs)
Top Reported Reactions
Lack of efficacy - NOS 3
Digestive tract disorder NOS 2
Diarrhoea 2
Lack of efficacy (endoparasite) - hookworm 1
Depression 1
Most Referenced Drugs
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 1
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 1
Spinosad 1
Rabies Vaccine 1
Oclacitinib Maleate 1
Outcome Breakdown
Ongoing
5 (71.4%)
Died
1 (14.3%)
Outcome Unknown
1 (14.3%)
Gender Distribution
Male 4 (57.1%)
Female 3 (42.9%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 1 | |
| 2014 | 2 | |
| 2015 | 1 | |
| 2016 | 1 | |
| 2019 | 1 | |
| 2024 | 1 | |
Tosa Pet Health Insights
Tosa accounts for 7 FDA adverse event reports, ranking #459 by volume among dog breeds, with 1 reports (14.3%) coded as a death outcome. Mean age at report: 5.7 years, average weight 54.7 kg (120.6 lbs).
Top reported signs: Lack of efficacy - NOS (3), Digestive tract disorder NOS (2), Diarrhoea (2). Most-referenced drug: Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg (1 reports), followed by Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg (1) and Spinosad (1).
Outcome coding on 7 status-recorded reports is dominated by Ongoing (71.4%). Annual submissions ranged 2,012-2,024 across 6 years on file.
Dog Breeds With a Similar Report Volume
Buhund - Norwegian
7 reports · 0.0% death rate
Coolie (German Coolie or Australian Coolie
7 reports · 14.3% death rate
Hound - Bavarian Mountain
7 reports · 0.0% death rate
Hound - Finnish
7 reports · 0.0% death rate
Hound - Italian
7 reports · 0.0% death rate
Shepherd Dog - Belgian Laekenois
7 reports · 0.0% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Tosa? ▼
There are 7 adverse event reports involving Tosa in the FDA database, with 1 reports involving death (14.3% death rate). Tosa ranks #459 by report volume.
What are the most common adverse reactions reported for Tosa? ▼
The most commonly reported adverse reactions for Tosa are Lack of efficacy - NOS (3 reports), Digestive tract disorder NOS (2 reports), Diarrhoea (2 reports), Lack of efficacy (endoparasite) - hookworm (1 reports), Depression (1 reports).
What drugs are most frequently associated with Tosa adverse events? ▼
The drugs most frequently referenced in Tosa adverse event reports are Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg (1 reports), Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg (1 reports), Spinosad (1 reports), Rabies Vaccine (1 reports), Oclacitinib Maleate (1 reports).
What is the average age of Tosa in adverse event reports? ▼
The average age of Tosa at the time of adverse event reports is 5.7 years, with an average weight of 54.7 kg (120.6 lbs).
Does a high number of adverse event reports mean Tosa is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Tosa safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.