Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
333
Total Reports
16
Deaths Reported
480.0%
Death Rate
7.9 yr
Avg Age at Report
Average weight at time of report: 8.5 kg (18.7 lbs)
Top Reported Reactions
Vomiting 62
Lethargy (see also Central nervous system depression in 'Neurological') 38
Diarrhoea 37
Emesis 26
Lack of efficacy - NOS 24
Seizure NOS 21
Lack of efficacy (ectoparasite) - flea 20
Digestive tract disorder NOS 18
Lack of efficacy (endoparasite) - hookworm 17
Pruritus 16
Ataxia 14
Behavioural disorder NOS 14
INEFFECTIVE, ASCARIDS NOS 13
Elevated serum alkaline phosphatase (SAP) 13
INEFFECTIVE, HEARTWORM LARVAE 11
Most Referenced Drugs
Milbemycin Oxime + Spinosad 59
Spinosad 38
Ivermectin + Pyrantel As Pamoate Salt 32
Afoxolaner 27
Trilostane 14
Selamectin 12
Milbemycin Oxime + Praziquantel 12
Fluralaner Chew Tablets 9
Bedinvetmab 8
Cyclosporine 7
Imidacloprid + Moxidectin 7
Carprofen 7
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 6
Oclacitinib Maleate 6
Moxidectin 6
Outcome Breakdown
Recovered/Normal
113 (37.8%)
Outcome Unknown
103 (34.4%)
Ongoing
50 (16.7%)
Recovered with Sequela
17 (5.7%)
Euthanized
10 (3.3%)
Died
6 (2.0%)
Gender Distribution
Female 179 (53.8%)
Male 144 (43.2%)
Unknown 8 (2.4%)
Mixed 2 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 17 | |
| 2011 | 31 | |
| 2012 | 27 | |
| 2013 | 34 | |
| 2014 | 38 | |
| 2015 | 28 | |
| 2016 | 33 | |
| 2017 | 29 | |
| 2018 | 16 | |
| 2019 | 13 | |
| 2020 | 14 | |
| 2021 | 16 | |
| 2022 | 9 | |
| 2023 | 9 | |
| 2024 | 10 | |
| 2025 | 9 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #160 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.