Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
6,836
Total Reports
301
Deaths Reported
440.0%
Death Rate
3.4 yr
Avg Age at Report
Average weight at time of report: 11.1 kg (24.5 lbs)
Top Reported Reactions
Vomiting 1,939
Emesis 645
Lethargy (see also Central nervous system depression in 'Neurological') 573
Diarrhoea 555
Seizure NOS 387
Lack of efficacy (ectoparasite) - flea 321
Lack of efficacy - NOS 268
Emesis (multiple) 234
Anorexia 228
Hives (see also 'Skin') 209
Lack of efficacy (endoparasite) - hookworm 196
Shaking 182
Lethargy (see also Central nervous system depression in Neurological) 170
Not eating 169
Death 165
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,313
Oclacitinib Maleate 708
Pyrantel Pamoate;Sarolaner 586
Afoxolaner 432
Moxidectin 406
Ivermectin + Pyrantel As Pamoate Salt 397
Fluralaner 13.64% 12-Week Chew 377
Spinosad 313
Fluralaner Chew Tablets 283
Anti-Il31 Mab Mcs Lot #1283563 244
Milbemycin Oxime + Praziquantel 213
Maropitant Citrate 173
Lotilaner 142
Sarolaner 140
Carprofen 128
Outcome Breakdown
Recovered/Normal
2,680 (40.5%)
Ongoing
2,001 (30.2%)
Outcome Unknown
1,496 (22.6%)
Died
187 (2.8%)
Recovered with Sequela
144 (2.2%)
Euthanized
115 (1.7%)
Gender Distribution
Male 3,578 (52.3%)
Female 3,055 (44.7%)
Unknown 166 (2.4%)
Mixed 37 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 112 | |
| 2011 | 171 | |
| 2012 | 314 | |
| 2013 | 303 | |
| 2014 | 311 | |
| 2015 | 367 | |
| 2016 | 433 | |
| 2017 | 450 | |
| 2018 | 466 | |
| 2019 | 499 | |
| 2020 | 506 | |
| 2021 | 547 | |
| 2022 | 504 | |
| 2023 | 576 | |
| 2024 | 736 | |
| 2025 | 541 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #33 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.