Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
15,583
Total Reports
574
Deaths Reported
370.0%
Death Rate
4.5 yr
Avg Age at Report
Average weight at time of report: 19.9 kg (43.9 lbs)
Top Reported Reactions
Vomiting 3,458
Lethargy (see also Central nervous system depression in 'Neurological') 1,215
Emesis 1,194
Lack of efficacy (endoparasite) - heartworm 1,155
Diarrhoea 1,148
Lack of efficacy (endoparasite) - hookworm 834
Seizure NOS 773
Lack of efficacy (ectoparasite) - flea 718
Lack of efficacy - NOS 634
INEFFECTIVE, HEARTWORM LARVAE 606
Lack of efficacy (ectoparasite) - tick NOS 499
Lack of efficacy (bacteria) - Borrelia 437
Anorexia 404
Lack of efficacy (endoparasite) - roundworm NOS 399
Ataxia 358
Most Referenced Drugs
Milbemycin Oxime + Spinosad 2,924
Ivermectin + Pyrantel As Pamoate Salt 1,769
Pyrantel Pamoate;Sarolaner 1,517
Afoxolaner 1,295
Milbemycin Oxime + Praziquantel 1,075
Moxidectin 953
Fluralaner 13.64% 12-Week Chew 636
Fluralaner Chew Tablets 620
Spinosad 595
Sarolaner 402
Bedinvetmab 397
Carprofen 395
Lotilaner 383
Oclacitinib Maleate 319
Milbemycin Oxime 227
Outcome Breakdown
Recovered/Normal
5,134 (34.3%)
Outcome Unknown
4,619 (30.9%)
Ongoing
4,153 (27.8%)
Recovered with Sequela
478 (3.2%)
Died
297 (2.0%)
Euthanized
277 (1.9%)
Gender Distribution
Female 7,747 (49.7%)
Male 7,510 (48.2%)
Unknown 274 (1.8%)
Mixed 52 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 354 | |
| 2011 | 383 | |
| 2012 | 747 | |
| 2013 | 850 | |
| 2014 | 847 | |
| 2015 | 926 | |
| 2016 | 913 | |
| 2017 | 1,046 | |
| 2018 | 1,007 | |
| 2019 | 1,110 | |
| 2020 | 1,191 | |
| 2021 | 1,145 | |
| 2022 | 1,220 | |
| 2023 | 1,322 | |
| 2024 | 1,492 | |
| 2025 | 1,030 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #13 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.