Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
9,399
Total Reports
418
Deaths Reported
440.0%
Death Rate
4.8 yr
Avg Age at Report
Average weight at time of report: 25.3 kg (55.8 lbs)
Top Reported Reactions
Vomiting 1,818
Lack of efficacy (endoparasite) - heartworm 805
Lethargy (see also Central nervous system depression in 'Neurological') 788
Diarrhoea 735
Emesis 671
Seizure NOS 556
INEFFECTIVE, HEARTWORM LARVAE 454
Lack of efficacy (ectoparasite) - flea 450
Lack of efficacy - NOS 431
Lack of efficacy (endoparasite) - hookworm 387
Anorexia 292
Ataxia 250
Lack of efficacy (bacteria) - Borrelia 247
Lack of efficacy (ectoparasite) - tick NOS 243
Digestive tract disorder NOS 236
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,733
Ivermectin + Pyrantel As Pamoate Salt 1,060
Pyrantel Pamoate;Sarolaner 811
Moxidectin 699
Afoxolaner 606
Milbemycin Oxime + Praziquantel 489
Spinosad 407
Sarolaner 343
Fluralaner Chew Tablets 338
Fluralaner 13.64% 12-Week Chew 312
Carprofen 301
Bedinvetmab 297
Trilostane 155
Melarsomine Dihydrochloride 153
Oclacitinib Maleate 153
Outcome Breakdown
Outcome Unknown
2,894 (32.1%)
Recovered/Normal
2,829 (31.4%)
Ongoing
2,546 (28.3%)
Recovered with Sequela
315 (3.5%)
Died
235 (2.6%)
Euthanized
183 (2.0%)
Gender Distribution
Female 4,802 (51.1%)
Male 4,396 (46.8%)
Unknown 177 (1.9%)
Mixed 24 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 224 | |
| 2011 | 286 | |
| 2012 | 474 | |
| 2013 | 469 | |
| 2014 | 546 | |
| 2015 | 559 | |
| 2016 | 605 | |
| 2017 | 666 | |
| 2018 | 678 | |
| 2019 | 736 | |
| 2020 | 744 | |
| 2021 | 636 | |
| 2022 | 679 | |
| 2023 | 752 | |
| 2024 | 824 | |
| 2025 | 521 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #20 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.