Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
219
Total Reports
11
Deaths Reported
500.0%
Death Rate
7.1 yr
Avg Age at Report
Average weight at time of report: 7.8 kg (17.2 lbs)
Top Reported Reactions
Vomiting 55
Lethargy (see also Central nervous system depression in 'Neurological') 29
Emesis 21
Lack of efficacy (ectoparasite) - flea 17
Diarrhoea 16
Lack of efficacy (endoparasite) - hookworm 13
Behavioural disorder NOS 13
Digestive tract disorder NOS 10
Elevated alanine aminotransferase (ALT) 9
Ataxia 8
Seizure NOS 8
Anorexia 8
Lack of efficacy - NOS 8
Death by euthanasia 7
Emesis (multiple) 7
Most Referenced Drugs
Milbemycin Oxime + Spinosad 47
Spinosad 21
Afoxolaner 17
Pyrantel Pamoate;Sarolaner 17
Ivermectin + Pyrantel As Pamoate Salt 11
Fluralaner Chew Tablets 11
Fluralaner 13.64% 12-Week Chew 10
Pimobendan 6
Oclacitinib Maleate 6
Sarolaner 6
Spinosad, Milbemycin 5
Selamectin 5
Ivermectin 5
Trilostane 5
Afoxolaner 28.3 Mg Chewable Tablets 5
Outcome Breakdown
Recovered/Normal
86 (43.4%)
Ongoing
52 (26.3%)
Outcome Unknown
44 (22.2%)
Euthanized
6 (3.0%)
Died
5 (2.5%)
Recovered with Sequela
5 (2.5%)
Gender Distribution
Male 124 (56.6%)
Female 87 (39.7%)
Unknown 8 (3.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 12 | |
| 2011 | 12 | |
| 2012 | 17 | |
| 2013 | 17 | |
| 2014 | 20 | |
| 2015 | 20 | |
| 2016 | 14 | |
| 2017 | 23 | |
| 2018 | 8 | |
| 2019 | 9 | |
| 2020 | 13 | |
| 2021 | 11 | |
| 2022 | 12 | |
| 2023 | 11 | |
| 2024 | 11 | |
| 2025 | 9 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #178 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.