Total Reports
331
FDA CVM filings
Dog /
FDA CVM · 2025 release 331 reports on file
Spitz - Dutch (Keeshond) - FDA Adverse Event Profile
Adverse-event records for Spitz - Dutch (Keeshond) (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Among dog breeds, Spitz - Dutch (Keeshond) is #161 by FDA report volume; 6.9% of its 331 reports (23) were death-coded.
- #161
- most-reported dog breed
- 6.9%
- death-coded report share
- 68
- Vomiting - top reaction
- 6.7 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
23
of 331 reports
Death Rate
6.9%
death-coded share
Avg Age at Report
6.7 yr
17.7 kg avg weight
Death-Coded Outcome Share
Spitz - Dutch (Keeshond) death-coded reports 6.9%
Cross-breed median
6.9% of 331 spitz - dutch (keeshond) reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 17.7 kg (39.0 lbs)
Top Reported Reactions
Vomiting 68
Emesis 39
Diarrhoea 38
Lethargy (see also Central nervous system depression in 'Neurological') 32
Lack of efficacy (endoparasite) - hookworm 29
Lack of efficacy - NOS 26
Digestive tract disorder NOS 21
Lack of efficacy (ectoparasite) - flea 16
Most Referenced Drugs
Milbemycin Oxime + Spinosad 66
Ivermectin + Pyrantel As Pamoate Salt 37
Afoxolaner 21
Fluralaner Chew Tablets 18
Trilostane 17
Spinosad 15
Milbemycin Oxime + Praziquantel 11
Nitenpyram 10
Outcome Breakdown
Recovered/Normal
114 (38.3%)
Outcome Unknown
95 (31.9%)
Ongoing
59 (19.8%)
Euthanized
13 (4.4%)
Died
10 (3.4%)
Recovered with Sequela
7 (2.3%)
Gender Distribution
Male 166 (50.2%)
Female 161 (48.6%)
Unknown 4 (1.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 15 | |
| 2011 | 30 | |
| 2012 | 42 | |
| 2013 | 38 | |
| 2014 | 33 | |
| 2015 | 20 | |
| 2016 | 27 | |
| 2017 | 15 | |
| 2018 | 31 | |
| 2019 | 13 | |
| 2020 | 19 | |
| 2021 | 9 | |
| 2022 | 18 | |
| 2023 | 5 | |
| 2024 | 7 | |
| 2025 | 9 | |
Spitz - Dutch (Keeshond) Pet Health Insights
Spitz - Dutch (Keeshond) accounts for 331 FDA adverse event reports, ranking #161 by volume among dog breeds, with 23 reports (6.9%) coded as a death outcome. Mean age at report: 6.7 years, average weight 17.7 kg (39.0 lbs).
Top reported signs: Vomiting (68), Emesis (39), Diarrhoea (38). Most-referenced drug: Milbemycin Oxime + Spinosad (66 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (37) and Afoxolaner (21).
Outcome coding on 298 status-recorded reports is dominated by Recovered/Normal (38.3%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Frequently Asked Questions
How many FDA adverse event reports involve Spitz - Dutch (Keeshond)? ▼
There are 331 adverse event reports involving Spitz - Dutch (Keeshond) in the FDA database, with 23 reports involving death (6.9% death rate). Spitz - Dutch (Keeshond) ranks #161 by report volume.
What are the most common adverse reactions reported for Spitz - Dutch (Keeshond)? ▼
The most commonly reported adverse reactions for Spitz - Dutch (Keeshond) are Vomiting (68 reports), Emesis (39 reports), Diarrhoea (38 reports), Lethargy (see also Central nervous system depression in 'Neurological') (32 reports), Lack of efficacy (endoparasite) - hookworm (29 reports).
What drugs are most frequently associated with Spitz - Dutch (Keeshond) adverse events? ▼
The drugs most frequently referenced in Spitz - Dutch (Keeshond) adverse event reports are Milbemycin Oxime + Spinosad (66 reports), Ivermectin + Pyrantel As Pamoate Salt (37 reports), Afoxolaner (21 reports), Fluralaner Chew Tablets (18 reports), Trilostane (17 reports).
What is the average age of Spitz - Dutch (Keeshond) in adverse event reports? ▼
The average age of Spitz - Dutch (Keeshond) at the time of adverse event reports is 6.7 years, with an average weight of 17.7 kg (39.0 lbs).
Does a high number of adverse event reports mean Spitz - Dutch (Keeshond) is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Spitz - Dutch (Keeshond) safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.