Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
331
Total Reports
23
Deaths Reported
690.0%
Death Rate
6.7 yr
Avg Age at Report
Average weight at time of report: 17.7 kg (39.0 lbs)
Top Reported Reactions
Vomiting 68
Emesis 39
Diarrhoea 38
Lethargy (see also Central nervous system depression in 'Neurological') 32
Lack of efficacy (endoparasite) - hookworm 29
Lack of efficacy - NOS 26
Digestive tract disorder NOS 21
Lack of efficacy (ectoparasite) - flea 16
Anorexia 15
Pruritus 15
Seizure NOS 13
INEFFECTIVE, HEARTWORM LARVAE 12
INEFFECTIVE, ASCARIDS NOS 11
Death by euthanasia 11
Other abnormal test result NOS 11
Most Referenced Drugs
Milbemycin Oxime + Spinosad 66
Ivermectin + Pyrantel As Pamoate Salt 37
Afoxolaner 21
Fluralaner Chew Tablets 18
Trilostane 17
Spinosad 15
Milbemycin Oxime + Praziquantel 11
Nitenpyram 10
Fluralaner 13.64% 12-Week Chew 10
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 9
Lotilaner 9
Ivermectin, Pyrantel 8
Cyclosporine A 8
Ivermectin/Pyrantel Pamoate/Praziquantel 8
Grapiprant 8
Outcome Breakdown
Recovered/Normal
114 (38.3%)
Outcome Unknown
95 (31.9%)
Ongoing
59 (19.8%)
Euthanized
13 (4.4%)
Died
10 (3.4%)
Recovered with Sequela
7 (2.3%)
Gender Distribution
Male 166 (50.2%)
Female 161 (48.6%)
Unknown 4 (1.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 15 | |
| 2011 | 30 | |
| 2012 | 42 | |
| 2013 | 38 | |
| 2014 | 33 | |
| 2015 | 20 | |
| 2016 | 27 | |
| 2017 | 15 | |
| 2018 | 31 | |
| 2019 | 13 | |
| 2020 | 19 | |
| 2021 | 9 | |
| 2022 | 18 | |
| 2023 | 5 | |
| 2024 | 7 | |
| 2025 | 9 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #161 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.