Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,607
Total Reports
116
Deaths Reported
440.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 26.7 kg (58.9 lbs)
Top Reported Reactions
Vomiting 510
Lethargy (see also Central nervous system depression in 'Neurological') 248
Lack of efficacy (endoparasite) - heartworm 207
Diarrhoea 192
Emesis 170
Lack of efficacy - NOS 154
Hives (see also 'Skin') 138
Lack of efficacy (endoparasite) - hookworm 128
INEFFECTIVE, HEARTWORM LARVAE 98
Facial swelling (see also 'Skin') 97
Seizure NOS 96
Anorexia 87
Lack of efficacy (ectoparasite) - flea 76
Death by euthanasia 68
Lethargy (see also Central nervous system depression in Neurological) 66
Most Referenced Drugs
Moxidectin 322
Milbemycin Oxime + Spinosad 310
Ivermectin + Pyrantel As Pamoate Salt 274
Pyrantel Pamoate;Sarolaner 240
Oclacitinib Maleate 181
Bedinvetmab 140
Afoxolaner 127
Carprofen 86
Fluralaner Chew Tablets 85
Sarolaner 84
Spinosad 81
Melarsomine Dihydrochloride 53
Anti-Il31 Mab Mcs Lot #1283563 53
Gabapentin 53
Fluralaner 13.64% 12-Week Chew 53
Outcome Breakdown
Ongoing
851 (33.4%)
Recovered/Normal
756 (29.7%)
Outcome Unknown
734 (28.8%)
Recovered with Sequela
91 (3.6%)
Euthanized
70 (2.7%)
Died
46 (1.8%)
Gender Distribution
Female 1,375 (52.7%)
Male 1,192 (45.7%)
Unknown 37 (1.4%)
Mixed 3 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 25 | |
| 2011 | 52 | |
| 2012 | 94 | |
| 2013 | 133 | |
| 2014 | 152 | |
| 2015 | 194 | |
| 2016 | 196 | |
| 2017 | 211 | |
| 2018 | 155 | |
| 2019 | 189 | |
| 2020 | 160 | |
| 2021 | 223 | |
| 2022 | 185 | |
| 2023 | 178 | |
| 2024 | 296 | |
| 2025 | 164 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #68 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.