Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
426
Total Reports
22
Deaths Reported
520.0%
Death Rate
6.4 yr
Avg Age at Report
Average weight at time of report: 9.9 kg (21.8 lbs)
Top Reported Reactions
Vomiting 97
Lethargy (see also Central nervous system depression in 'Neurological') 51
Diarrhoea 29
Emesis 27
Lack of efficacy (endoparasite) - heartworm 27
Lack of efficacy (ectoparasite) - flea 22
Lack of efficacy - NOS 20
Other abnormal test result NOS 18
Seizure NOS 18
Lack of efficacy (endoparasite) - hookworm 17
Behavioural disorder NOS 16
Shaking 16
Ataxia 14
Anorexia 12
INEFFECTIVE, HEARTWORM LARVAE 12
Most Referenced Drugs
Milbemycin Oxime + Spinosad 93
Ivermectin + Pyrantel As Pamoate Salt 36
Afoxolaner 35
Oclacitinib Maleate 31
Milbemycin Oxime + Praziquantel 24
Trilostane 20
Pyrantel Pamoate;Sarolaner 20
Spinosad 16
Fluralaner 13.64% 12-Week Chew 15
Cyclosporine A 14
Fluralaner Chew Tablets 13
Moxidectin 12
Carprofen 10
Selamectin 9
Sarolaner 8
Outcome Breakdown
Recovered/Normal
149 (35.0%)
Outcome Unknown
138 (32.4%)
Ongoing
106 (24.9%)
Died
12 (2.8%)
Recovered with Sequela
11 (2.6%)
Euthanized
10 (2.3%)
Gender Distribution
Male 212 (49.8%)
Female 207 (48.6%)
Unknown 7 (1.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 8 | |
| 2012 | 35 | |
| 2013 | 29 | |
| 2014 | 29 | |
| 2015 | 25 | |
| 2016 | 45 | |
| 2017 | 35 | |
| 2018 | 35 | |
| 2019 | 23 | |
| 2020 | 31 | |
| 2021 | 38 | |
| 2022 | 20 | |
| 2023 | 35 | |
| 2024 | 23 | |
| 2025 | 15 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #149 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.