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2026 FDA CVM data 426 reports on file official source

Terrier - Fox Wire — FDA Adverse Event Profile

Adverse-event records and label data for Terrier - Fox Wire (Dog), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.

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Annual breed adverse-event registration timeline Bar chart showing yearly FDA Center for Veterinary Medicine adverse event report counts per breed registry cohort, with paw-print tick marks indicating count buckets. 38 28.5 19 9.5 0 2018 2019 2020 2021 2022 2023 2024 2025 Reports filed Death-coded reports
Annual report volume for Terrier - Fox Wire drawn from FDA CVM filings.

Terrier - Fox Wire (Dog) has 426 FDA adverse event reports on record, with 22 deaths reported (520.0% death rate) — ranking #149 by report volume. The most frequently reported reaction is Vomiting (97 cases). The top associated drug is Milbemycin Oxime + Spinosad. Average age at report: 6.4 years.

Total Reports

426

FDA CVM filings

Deaths Reported

22

of 426 reports

Death Rate

520.0%

death-coded share

Avg Age at Report

6.4 yr

9.9 kg avg weight

Death-Coded Outcome Share

Terrier - Fox Wire death-coded reports 100.0%
Database median

520.0% of 426 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Average weight at time of report: 9.9 kg (21.8 lbs)

Top Reported Reactions

Vomiting 97
Lethargy (see also Central nervous system depression in 'Neurological') 51
Diarrhoea 29
Emesis 27
Lack of efficacy (endoparasite) - heartworm 27
Lack of efficacy (ectoparasite) - flea 22
Lack of efficacy - NOS 20
Other abnormal test result NOS 18
Seizure NOS 18
Lack of efficacy (endoparasite) - hookworm 17
Behavioural disorder NOS 16
Shaking 16
Ataxia 14
Anorexia 12
INEFFECTIVE, HEARTWORM LARVAE 12

Most Referenced Drugs

Milbemycin Oxime + Spinosad 93
Ivermectin + Pyrantel As Pamoate Salt 36
Afoxolaner 35
Oclacitinib Maleate 31
Milbemycin Oxime + Praziquantel 24
Trilostane 20
Pyrantel Pamoate;Sarolaner 20
Spinosad 16
Fluralaner 13.64% 12-Week Chew 15
Cyclosporine A 14
Fluralaner Chew Tablets 13
Moxidectin 12
Carprofen 10
Selamectin 9
Sarolaner 8

Outcome Breakdown

Recovered/Normal
149 (35.0%)
Outcome Unknown
138 (32.4%)
Ongoing
106 (24.9%)
Died
12 (2.8%)
Recovered with Sequela
11 (2.6%)
Euthanized
10 (2.3%)

Gender Distribution

Male 212 (49.8%)
Female 207 (48.6%)
Unknown 7 (1.6%)

Reports by Year

Year Reports Trend
2011 8
2012 35
2013 29
2014 29
2015 25
2016 45
2017 35
2018 35
2019 23
2020 31
2021 38
2022 20
2023 35
2024 23
2025 15
Size-class weight distribution across registered breeds Vertical bar chart showing the distribution of registered breeds across five size classes (Toy, Small, Medium, Large, Giant), each represented by a scaled dog-silhouette and a count value. 118 89 59 30 0 Breeds in class 38 Toy 0–6 kg Chihuahua 64 Small 6–14 kg Beagle 92 Medium 14–27 kg Border Collie 118 Large 27–45 kg Labrador Retriever 41 Giant 45–90 kg Great Dane Size-Class Distribution
Where Terrier - Fox Wire sits in the registered size-class taxonomy. Average reported weight: 9.9 kg.
Breed-group distribution donut chart Donut chart with kennel-club-ribbon center showing breed counts across the eight standard breed groups (Sporting, Hound, Working, Terrier, Toy, Non-Sporting, Herding, Miscellaneous). CH Sporting 32 · 14.2% Hound 36 · 15.9% Working 33 · 14.6% Terrier 31 · 13.7% Toy 23 · 10.2% Non-Sporting 21 · 9.3% Herding 32 · 14.2% Misc. 18 · 8.0% Breed-Group Classification 226 breeds across 8 taxonomic groups
Eight standard breed-group classifications used by major registries (AKC's seven groups plus Miscellaneous). Provides taxonomic context for breed lookups.

Terrier - Fox Wire Pet Health Insights

Across the FDA Center for Veterinary Medicine adverse event database, Terrier - Fox Wire accounts for 426 submitted reports and currently ranks #149 by report volume within the dog population. Of those reports, 22 involved a death outcome — a 520.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 6.4 years, with an average recorded body weight of 9.9 kg (21.8 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.

The most frequently reported clinical signs for Terrier - Fox Wire are Vomiting (97 reports), Lethargy (see also Central nervous system depression in 'Neurological') (51 reports), Diarrhoea (29 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Milbemycin Oxime + Spinosad appears in 93 reports and is the single most-referenced drug, followed by Ivermectin + Pyrantel As Pamoate Salt (36) and Afoxolaner (35). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same dog species.

Outcome coding on the 426 reports with a recorded status is dominated by Recovered/Normal (35.0% of coded outcomes). Annual submission volume ranges from 2,011 to 2,025 reports across the 15 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual dog.

Understanding Terrier - Fox Wire Adverse Event Data

Terrier - Fox Wire has 426 adverse event reports on file. Lower report volumes may reflect a less common breed, lower reporting rates, or genuinely fewer adverse events.

The 520.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.

The most frequently referenced drug in adverse reports is Milbemycin Oxime + Spinosad, appearing in 93 reports. This may indicate widespread use of the medication rather than a specific safety concern for Terrier - Fox Wire.

Other Dog Breeds

Frequently Asked Questions

How many FDA adverse event reports involve Terrier - Fox Wire?
There are 426 adverse event reports involving Terrier - Fox Wire in the FDA database, with 22 reports involving death (520.0% death rate). Terrier - Fox Wire ranks #149 by report volume.
What are the most common adverse reactions reported for Terrier - Fox Wire?
The most commonly reported adverse reactions for Terrier - Fox Wire are Vomiting (97 reports), Lethargy (see also Central nervous system depression in 'Neurological') (51 reports), Diarrhoea (29 reports), Emesis (27 reports), Lack of efficacy (endoparasite) - heartworm (27 reports).
What drugs are most frequently associated with Terrier - Fox Wire adverse events?
The drugs most frequently referenced in Terrier - Fox Wire adverse event reports are Milbemycin Oxime + Spinosad (93 reports), Ivermectin + Pyrantel As Pamoate Salt (36 reports), Afoxolaner (35 reports), Oclacitinib Maleate (31 reports), Milbemycin Oxime + Praziquantel (24 reports).
What is the average age of Terrier - Fox Wire in adverse event reports?
The average age of Terrier - Fox Wire at the time of adverse event reports is 6.4 years, with an average weight of 9.9 kg (21.8 lbs).
Does a high number of adverse event reports mean Terrier - Fox Wire is unhealthy?
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Terrier - Fox Wire safety data come from?
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.

Guides & Resources

Related Data Sources

Data Sources & Methodology

Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.

Terrier - Fox Wire ranks #149 by total report volume. Death rate (520.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial