Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
68,210
Total Reports
2,161
Deaths Reported
320.0%
Death Rate
5.3 yr
Avg Age at Report
Average weight at time of report: 19.4 kg (42.8 lbs)
Top Reported Reactions
Vomiting 15,157
INEFFECTIVE, HEARTWORM LARVAE 5,941
Lack of efficacy (endoparasite) - heartworm 4,990
Lack of efficacy (ectoparasite) - flea 4,738
Lethargy (see also Central nervous system depression in 'Neurological') 4,285
Diarrhoea 4,148
Lack of efficacy (endoparasite) - hookworm 3,866
Lack of efficacy - NOS 3,057
Emesis 2,962
Anorexia 2,332
Emesis (multiple) 2,288
Digestive tract disorder NOS 2,002
Depression 1,800
Seizure NOS 1,781
INEFFECTIVE, ASCARIDS NOS 1,640
Most Referenced Drugs
Fluralaner Chew Tablets 7,461
Milbemycin Oxime + Spinosad 6,856
Fluralaner 13.64% 12-Week Chew 6,200
Ivermectin + Pyrantel As Pamoate Salt 5,910
Spinosad 4,539
Ivermectin, Pyrantel 2,930
Pyrantel Pamoate;Sarolaner 2,348
Afoxolaner 2,283
Moxidectin 1,983
Milbemycin Oxime + Praziquantel 1,694
Milbemycin 1,422
Ivermectin + Pyrantel 1,308
Carprofen 1,188
Melarsomine Dihydrochloride 1,133
Milbemycin/Lufenuron/Pzq Chew 1,084
Outcome Breakdown
Recovered/Normal
18,118 (32.8%)
Outcome Unknown
15,977 (29.0%)
Ongoing
15,802 (28.6%)
Recovered with Sequela
3,106 (5.6%)
Died
1,345 (2.4%)
Euthanized
816 (1.5%)
Gender Distribution
Female 35,142 (51.5%)
Male 32,131 (47.1%)
Unknown 706 (1.0%)
Mixed 231 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 7,085 | |
| 2011 | 5,976 | |
| 2012 | 3,132 | |
| 2013 | 3,687 | |
| 2014 | 3,918 | |
| 2015 | 3,696 | |
| 2016 | 4,435 | |
| 2017 | 5,142 | |
| 2018 | 4,013 | |
| 2019 | 4,117 | |
| 2020 | 4,368 | |
| 2021 | 4,002 | |
| 2022 | 3,308 | |
| 2023 | 3,821 | |
| 2024 | 4,583 | |
| 2025 | 2,927 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #2 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.