Total Reports
68,210
FDA CVM filings
Dog /
FDA CVM · 2025 release 68,210 reports on file
Crossbred Canine/dog - FDA Adverse Event Profile
Adverse-event records for Crossbred Canine/dog (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 68,210 reports on file, Crossbred Canine/dog sits at #2 among dog breeds by volume; death-coded share is 3.2% (2,161 reports).
- #2
- most-reported dog breed
- 3.2%
- death-coded report share
- 15,157
- Vomiting - top reaction
- 5.3 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
2,161
of 68,210 reports
Death Rate
3.2%
death-coded share
Avg Age at Report
5.3 yr
19.4 kg avg weight
Death-Coded Outcome Share
Crossbred Canine/dog death-coded reports 3.2%
Cross-breed median
3.2% of 68,210 crossbred canine/dog reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 19.4 kg (42.8 lbs)
Top Reported Reactions
Vomiting 15,157
INEFFECTIVE, HEARTWORM LARVAE 5,941
Lack of efficacy (endoparasite) - heartworm 4,990
Lack of efficacy (ectoparasite) - flea 4,738
Lethargy (see also Central nervous system depression in 'Neurological') 4,285
Diarrhoea 4,148
Lack of efficacy (endoparasite) - hookworm 3,866
Lack of efficacy - NOS 3,057
Emesis 2,962
Anorexia 2,332
Emesis (multiple) 2,288
Digestive tract disorder NOS 2,002
Depression 1,800
Seizure NOS 1,781
INEFFECTIVE, ASCARIDS NOS 1,640
Most Referenced Drugs
Fluralaner Chew Tablets 7,461
Milbemycin Oxime + Spinosad 6,856
Fluralaner 13.64% 12-Week Chew 6,200
Ivermectin + Pyrantel As Pamoate Salt 5,910
Spinosad 4,539
Ivermectin, Pyrantel 2,930
Pyrantel Pamoate;Sarolaner 2,348
Afoxolaner 2,283
Moxidectin 1,983
Milbemycin Oxime + Praziquantel 1,694
Milbemycin 1,422
Ivermectin + Pyrantel 1,308
Carprofen 1,188
Melarsomine Dihydrochloride 1,133
Milbemycin/Lufenuron/Pzq Chew 1,084
Outcome Breakdown
Recovered/Normal
18,118 (32.8%)
Outcome Unknown
15,977 (29.0%)
Ongoing
15,802 (28.6%)
Recovered with Sequela
3,106 (5.6%)
Died
1,345 (2.4%)
Euthanized
816 (1.5%)
Gender Distribution
Female 35,142 (51.5%)
Male 32,131 (47.1%)
Unknown 706 (1.0%)
Mixed 231 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 7,085 | |
| 2011 | 5,976 | |
| 2012 | 3,132 | |
| 2013 | 3,687 | |
| 2014 | 3,918 | |
| 2015 | 3,696 | |
| 2016 | 4,435 | |
| 2017 | 5,142 | |
| 2018 | 4,013 | |
| 2019 | 4,117 | |
| 2020 | 4,368 | |
| 2021 | 4,002 | |
| 2022 | 3,308 | |
| 2023 | 3,821 | |
| 2024 | 4,583 | |
| 2025 | 2,927 | |
Crossbred Canine/dog Pet Health Insights
Crossbred Canine/dog accounts for 68,210 FDA adverse event reports, ranking #2 by volume among dog breeds, with 2,161 reports (3.2%) coded as a death outcome. Mean age at report: 5.3 years, average weight 19.4 kg (42.8 lbs).
Top reported signs: Vomiting (15,157), INEFFECTIVE, HEARTWORM LARVAE (5,941), Lack of efficacy (endoparasite) - heartworm (4,990). Most-referenced drug: Fluralaner Chew Tablets (7,461 reports), followed by Milbemycin Oxime + Spinosad (6,856) and Fluralaner 13.64% 12-Week Chew (6,200).
Outcome coding on 55,164 status-recorded reports is dominated by Recovered/Normal (32.8%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Dog (unknown)
47,381 reports · 8.7% death rate
Retriever - Labrador
90,806 reports · 3.6% death rate
Retriever - Golden
34,475 reports · 3.7% death rate
Shepherd Dog - German
31,142 reports · 4.3% death rate
Chihuahua
30,657 reports · 4.2% death rate
Terrier - Yorkshire
24,408 reports · 3.7% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Crossbred Canine/dog? ▼
There are 68,210 adverse event reports involving Crossbred Canine/dog in the FDA database, with 2,161 reports involving death (3.2% death rate). Crossbred Canine/dog ranks #2 by report volume.
What are the most common adverse reactions reported for Crossbred Canine/dog? ▼
The most commonly reported adverse reactions for Crossbred Canine/dog are Vomiting (15,157 reports), INEFFECTIVE, HEARTWORM LARVAE (5,941 reports), Lack of efficacy (endoparasite) - heartworm (4,990 reports), Lack of efficacy (ectoparasite) - flea (4,738 reports), Lethargy (see also Central nervous system depression in 'Neurological') (4,285 reports).
What drugs are most frequently associated with Crossbred Canine/dog adverse events? ▼
The drugs most frequently referenced in Crossbred Canine/dog adverse event reports are Fluralaner Chew Tablets (7,461 reports), Milbemycin Oxime + Spinosad (6,856 reports), Fluralaner 13.64% 12-Week Chew (6,200 reports), Ivermectin + Pyrantel As Pamoate Salt (5,910 reports), Spinosad (4,539 reports).
What is the average age of Crossbred Canine/dog in adverse event reports? ▼
The average age of Crossbred Canine/dog at the time of adverse event reports is 5.3 years, with an average weight of 19.4 kg (42.8 lbs).
Does a high number of adverse event reports mean Crossbred Canine/dog is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Crossbred Canine/dog safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.