Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,555
Total Reports
65
Deaths Reported
420.0%
Death Rate
5.2 yr
Avg Age at Report
Average weight at time of report: 12.9 kg (28.4 lbs)
Top Reported Reactions
Vomiting 338
Emesis 166
Lethargy (see also Central nervous system depression in 'Neurological') 160
Diarrhoea 158
Lack of efficacy (endoparasite) - hookworm 106
Lack of efficacy (ectoparasite) - flea 81
Digestive tract disorder NOS 70
Lack of efficacy - NOS 63
Emesis (multiple) 60
Seizure NOS 50
Behavioural disorder NOS 49
Other abnormal test result NOS 42
Lack of efficacy (endoparasite) - heartworm 41
Anorexia 39
Lack of efficacy (endoparasite) - roundworm NOS 39
Most Referenced Drugs
Milbemycin Oxime + Spinosad 355
Ivermectin + Pyrantel As Pamoate Salt 162
Pyrantel Pamoate;Sarolaner 122
Fluralaner Chew Tablets 117
Afoxolaner 110
Fluralaner 13.64% 12-Week Chew 82
Imidacloprid + Moxidectin 59
Spinosad 57
Trilostane 57
Milbemycin Oxime + Praziquantel 55
Carprofen 37
Lotilaner 36
Moxidectin 32
Ivermectin + Pyrantel 29
Oclacitinib Maleate 27
Outcome Breakdown
Recovered/Normal
627 (40.3%)
Outcome Unknown
449 (28.8%)
Ongoing
368 (23.6%)
Recovered with Sequela
47 (3.0%)
Died
35 (2.2%)
Euthanized
31 (2.0%)
Gender Distribution
Male 765 (49.2%)
Female 752 (48.4%)
Unknown 32 (2.1%)
Mixed 6 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2011 | 14 | |
| 2012 | 77 | |
| 2013 | 141 | |
| 2014 | 103 | |
| 2015 | 108 | |
| 2016 | 142 | |
| 2017 | 128 | |
| 2018 | 126 | |
| 2019 | 106 | |
| 2020 | 110 | |
| 2021 | 98 | |
| 2022 | 102 | |
| 2023 | 108 | |
| 2024 | 108 | |
| 2025 | 83 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #87 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.