Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
7,526
Total Reports
345
Deaths Reported
460.0%
Death Rate
5.7 yr
Avg Age at Report
Average weight at time of report: 10.2 kg (22.5 lbs)
Top Reported Reactions
Vomiting 1,594
Emesis 831
Lethargy (see also Central nervous system depression in 'Neurological') 674
Diarrhoea 550
Lack of efficacy (endoparasite) - hookworm 435
Lack of efficacy - NOS 403
Seizure NOS 370
Lack of efficacy (ectoparasite) - flea 316
INEFFECTIVE, HEARTWORM LARVAE 265
Anorexia 238
Digestive tract disorder NOS 237
Lack of efficacy (endoparasite) - heartworm 236
Other abnormal test result NOS 220
Elevated alanine aminotransferase (ALT) 213
Behavioural disorder NOS 184
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,571
Trilostane 646
Ivermectin + Pyrantel As Pamoate Salt 639
Spinosad 555
Moxidectin 431
Afoxolaner 371
Oclacitinib Maleate 365
Pyrantel Pamoate;Sarolaner 322
Fluralaner Chew Tablets 298
Milbemycin Oxime + Praziquantel 224
Fluralaner 13.64% 12-Week Chew 149
Carprofen 139
Sarolaner 131
Selamectin 119
Maropitant Citrate 117
Outcome Breakdown
Recovered/Normal
2,580 (37.2%)
Outcome Unknown
2,152 (31.0%)
Ongoing
1,608 (23.2%)
Recovered with Sequela
257 (3.7%)
Died
187 (2.7%)
Euthanized
158 (2.3%)
Gender Distribution
Female 3,694 (49.1%)
Male 3,669 (48.8%)
Unknown 145 (1.9%)
Mixed 18 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 298 | |
| 2011 | 433 | |
| 2012 | 618 | |
| 2013 | 629 | |
| 2014 | 594 | |
| 2015 | 562 | |
| 2016 | 517 | |
| 2017 | 580 | |
| 2018 | 479 | |
| 2019 | 560 | |
| 2020 | 451 | |
| 2021 | 406 | |
| 2022 | 370 | |
| 2023 | 398 | |
| 2024 | 379 | |
| 2025 | 252 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #28 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.