Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
872
Total Reports
52
Deaths Reported
600.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 28.1 kg (62.0 lbs)
Top Reported Reactions
Vomiting 153
Diarrhoea 91
Emesis 76
Lethargy (see also Central nervous system depression in 'Neurological') 67
Lack of efficacy (endoparasite) - hookworm 57
Lack of efficacy - NOS 53
Lack of efficacy (endoparasite) - heartworm 43
Death by euthanasia 41
Anorexia 38
INEFFECTIVE, HEARTWORM LARVAE 34
Digestive tract disorder NOS 31
Other abnormal test result NOS 27
Elevated creatinine 24
Weight loss 24
INEFFECTIVE, ASCARIDS NOS 23
Most Referenced Drugs
Milbemycin Oxime + Spinosad 141
Ivermectin + Pyrantel As Pamoate Salt 92
Afoxolaner 90
Spinosad 48
Carprofen 46
Pyrantel Pamoate;Sarolaner 39
Milbemycin Oxime + Praziquantel 37
Oclacitinib Maleate 32
Moxidectin 31
Fluralaner Chew Tablets 26
Bedinvetmab 20
Sarolaner 19
Gabapentin 18
Ivermectin 17
Fluralaner 13.64% 12-Week Chew 16
Outcome Breakdown
Outcome Unknown
268 (34.1%)
Recovered/Normal
233 (29.6%)
Ongoing
202 (25.7%)
Recovered with Sequela
31 (3.9%)
Euthanized
27 (3.4%)
Died
25 (3.2%)
Gender Distribution
Male 432 (49.5%)
Female 419 (48.1%)
Unknown 19 (2.2%)
Mixed 2 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 47 | |
| 2011 | 56 | |
| 2012 | 71 | |
| 2013 | 64 | |
| 2014 | 60 | |
| 2015 | 66 | |
| 2016 | 53 | |
| 2017 | 61 | |
| 2018 | 53 | |
| 2019 | 56 | |
| 2020 | 62 | |
| 2021 | 34 | |
| 2022 | 46 | |
| 2023 | 49 | |
| 2024 | 47 | |
| 2025 | 47 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #114 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.