Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
339
Total Reports
14
Deaths Reported
410.0%
Death Rate
6.7 yr
Avg Age at Report
Average weight at time of report: 10.2 kg (22.5 lbs)
Top Reported Reactions
Vomiting 86
Lethargy (see also Central nervous system depression in 'Neurological') 51
Diarrhoea 46
Emesis 33
Lack of efficacy (endoparasite) - hookworm 20
Seizure NOS 17
Digestive tract disorder NOS 15
Lack of efficacy - NOS 13
Lack of efficacy (ectoparasite) - flea 12
Elevated alanine aminotransferase (ALT) 12
Itching 11
Elevated serum alkaline phosphatase (SAP) 11
Shaking 11
Weight loss 10
Other abnormal test result NOS 10
Most Referenced Drugs
Milbemycin Oxime + Spinosad 58
Ivermectin + Pyrantel As Pamoate Salt 34
Afoxolaner 32
Oclacitinib Maleate 28
Cyclosporine 16
Spinosad 16
Pyrantel Pamoate;Sarolaner 15
Moxidectin 14
Cyclosporine A 12
Trilostane 12
Fluralaner Chew Tablets 12
Anti-Il31 Mab Mcs Lot #1283563 12
Bedinvetmab 10
Fluralaner 13.64% 12-Week Chew 9
Sarolaner 7
Outcome Breakdown
Recovered/Normal
115 (36.4%)
Outcome Unknown
88 (27.8%)
Ongoing
85 (26.9%)
Recovered with Sequela
14 (4.4%)
Euthanized
9 (2.8%)
Died
5 (1.6%)
Gender Distribution
Male 175 (51.6%)
Female 162 (47.8%)
Mixed 1 (0.3%)
Unknown 1 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 13 | |
| 2011 | 14 | |
| 2012 | 31 | |
| 2013 | 23 | |
| 2014 | 34 | |
| 2015 | 35 | |
| 2016 | 26 | |
| 2017 | 28 | |
| 2018 | 26 | |
| 2019 | 19 | |
| 2020 | 13 | |
| 2021 | 13 | |
| 2022 | 15 | |
| 2023 | 13 | |
| 2024 | 21 | |
| 2025 | 15 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #159 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.