Total Reports
9,020
FDA CVM filings
Dog /
FDA CVM · 2025 release 9,020 reports on file
Pug - FDA Adverse Event Profile
Adverse-event records for Pug (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 9,020 reports on file, Pug sits at #22 among dog breeds by volume; death-coded share is 5.1% (461 reports).
- #22
- most-reported dog breed
- 5.1%
- death-coded report share
- 2,000
- Vomiting - top reaction
- 6.0 yr
- average age at report
Higher volume usually means a more popular breed, not a riskier one, compare against how common the breed is.
Deaths Reported
461
of 9,020 reports
Death Rate
5.1%
death-coded share
Avg Age at Report
6.0 yr
10.2 kg avg weight
Death-Coded Outcome Share
Pug death-coded reports 5.1%
Cross-breed median
5.1% of 9,020 pug reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 10.2 kg (22.5 lbs)
Top Reported Reactions
Vomiting 2,000
Emesis 1,124
Lethargy (see also Central nervous system depression in 'Neurological') 886
Diarrhoea 568
Lack of efficacy (ectoparasite) - flea 525
Lack of efficacy - NOS 505
Seizure NOS 379
Lack of efficacy (endoparasite) - hookworm 355
Anorexia 287
Digestive tract disorder NOS 249
Ataxia 247
Death 247
Behavioural disorder NOS 244
Other abnormal test result NOS 218
INEFFECTIVE, HEARTWORM LARVAE 210
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,812
Spinosad 865
Ivermectin + Pyrantel As Pamoate Salt 597
Moxidectin 517
Oclacitinib Maleate 487
Afoxolaner 483
Pyrantel Pamoate;Sarolaner 329
Fluralaner Chew Tablets 320
Carprofen 219
Milbemycin Oxime + Praziquantel 211
Fluralaner 13.64% 12-Week Chew 194
Sarolaner 170
Bedinvetmab 167
Maropitant Citrate 149
Selamectin 140
Outcome Breakdown
Recovered/Normal
3,341 (40.5%)
Outcome Unknown
2,261 (27.4%)
Ongoing
1,888 (22.9%)
Recovered with Sequela
306 (3.7%)
Died
286 (3.5%)
Euthanized
175 (2.1%)
Gender Distribution
Male 4,529 (50.2%)
Female 4,281 (47.5%)
Unknown 179 (2.0%)
Mixed 31 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 420 | |
| 2011 | 565 | |
| 2012 | 781 | |
| 2013 | 810 | |
| 2014 | 761 | |
| 2015 | 710 | |
| 2016 | 718 | |
| 2017 | 679 | |
| 2018 | 567 | |
| 2019 | 564 | |
| 2020 | 479 | |
| 2021 | 446 | |
| 2022 | 373 | |
| 2023 | 416 | |
| 2024 | 479 | |
| 2025 | 252 | |
Pug Pet Health Insights
Pug accounts for 9,020 FDA adverse event reports, ranking #22 by volume among dog breeds, with 461 reports (5.1%) coded as a death outcome. Mean age at report: 6.0 years, average weight 10.2 kg (22.5 lbs).
Top reported signs: Vomiting (2,000), Emesis (1,124), Lethargy (see also Central nervous system depression in 'Neurological') (886). Most-referenced drug: Milbemycin Oxime + Spinosad (1,812 reports), followed by Spinosad (865) and Ivermectin + Pyrantel As Pamoate Salt (597).
Outcome coding on 8,257 status-recorded reports is dominated by Recovered/Normal (40.5%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Spitz - German Pomeranian
8,853 reports · 5.0% death rate
Siberian Husky
9,399 reports · 4.4% death rate
Collie - Border
9,801 reports · 4.3% death rate
Terrier - Bull - American Pit
8,232 reports · 4.5% death rate
Terrier - Jack Russell
10,210 reports · 3.7% death rate
Cattle Dog - Australian (blue heeler, red heeler, Queensland cattledog)
7,541 reports · 3.6% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Pug? ▼
There are 9,020 adverse event reports involving Pug in the FDA database, with 461 reports involving death (5.1% death rate). Pug ranks #22 by report volume.
What are the most common adverse reactions reported for Pug? ▼
The most commonly reported adverse reactions for Pug are Vomiting (2,000 reports), Emesis (1,124 reports), Lethargy (see also Central nervous system depression in 'Neurological') (886 reports), Diarrhoea (568 reports), Lack of efficacy (ectoparasite) - flea (525 reports).
What drugs are most frequently associated with Pug adverse events? ▼
The drugs most frequently referenced in Pug adverse event reports are Milbemycin Oxime + Spinosad (1,812 reports), Spinosad (865 reports), Ivermectin + Pyrantel As Pamoate Salt (597 reports), Moxidectin (517 reports), Oclacitinib Maleate (487 reports).
What is the average age of Pug in adverse event reports? ▼
The average age of Pug at the time of adverse event reports is 6.0 years, with an average weight of 10.2 kg (22.5 lbs).
Does a high number of adverse event reports mean Pug is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Pug safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.