Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
9,020
Total Reports
461
Deaths Reported
510.0%
Death Rate
6.0 yr
Avg Age at Report
Average weight at time of report: 10.2 kg (22.5 lbs)
Top Reported Reactions
Vomiting 2,000
Emesis 1,124
Lethargy (see also Central nervous system depression in 'Neurological') 886
Diarrhoea 568
Lack of efficacy (ectoparasite) - flea 525
Lack of efficacy - NOS 505
Seizure NOS 379
Lack of efficacy (endoparasite) - hookworm 355
Anorexia 287
Digestive tract disorder NOS 249
Ataxia 247
Death 247
Behavioural disorder NOS 244
Other abnormal test result NOS 218
INEFFECTIVE, HEARTWORM LARVAE 210
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,812
Spinosad 865
Ivermectin + Pyrantel As Pamoate Salt 597
Moxidectin 517
Oclacitinib Maleate 487
Afoxolaner 483
Pyrantel Pamoate;Sarolaner 329
Fluralaner Chew Tablets 320
Carprofen 219
Milbemycin Oxime + Praziquantel 211
Fluralaner 13.64% 12-Week Chew 194
Sarolaner 170
Bedinvetmab 167
Maropitant Citrate 149
Selamectin 140
Outcome Breakdown
Recovered/Normal
3,341 (40.5%)
Outcome Unknown
2,261 (27.4%)
Ongoing
1,888 (22.9%)
Recovered with Sequela
306 (3.7%)
Died
286 (3.5%)
Euthanized
175 (2.1%)
Gender Distribution
Male 4,529 (50.2%)
Female 4,281 (47.5%)
Unknown 179 (2.0%)
Mixed 31 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 420 | |
| 2011 | 565 | |
| 2012 | 781 | |
| 2013 | 810 | |
| 2014 | 761 | |
| 2015 | 710 | |
| 2016 | 718 | |
| 2017 | 679 | |
| 2018 | 567 | |
| 2019 | 564 | |
| 2020 | 479 | |
| 2021 | 446 | |
| 2022 | 373 | |
| 2023 | 416 | |
| 2024 | 479 | |
| 2025 | 252 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #22 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.