Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
19
Total Reports
2
Deaths Reported
1050.0%
Death Rate
5.2 yr
Avg Age at Report
Average weight at time of report: 44.8 kg (98.8 lbs)
Top Reported Reactions
Lack of efficacy (ectoparasite) - flea 3
Vomiting 2
Fever 1
Alopecia 1
Unexplained death 1
INEFFECTIVE, HEARTWORM LARVAE 1
INEFFECTIVE, HOOKS 1
Application site bleeding 1
Weight loss 1
Anorexia 1
Leucocytosis NOS 1
Urinary tract infection 1
Drug administration error 1
Overdose 1
Lack of efficacy (endoparasite) - heartworm 1
Most Referenced Drugs
Oclacitinib Maleate 2
Fluralaner Chew Tablets 2
Milbemycin Oxime + Spinosad 2
Spinosad 2
Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate) 1
Milbemycin Oxime + Praziquantel 1
Afoxolaner 1
Citronella Oil 1
Tylosin Tartrate 1
Phenylpropanolamine Hcl 1
Levothyroxine 1
Ivermectin + Pyrantel As Pamoate Salt 1
Fipronil 1
Melarsomine Dihydrochloride 1
Doxycycline 1
Outcome Breakdown
Outcome Unknown
8 (42.1%)
Ongoing
5 (26.3%)
Recovered/Normal
3 (15.8%)
Died
2 (10.5%)
Recovered with Sequela
1 (5.3%)
Gender Distribution
Male 11 (57.9%)
Female 6 (31.6%)
Unknown 2 (10.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2014 | 1 | |
| 2015 | 1 | |
| 2017 | 3 | |
| 2018 | 2 | |
| 2019 | 2 | |
| 2020 | 2 | |
| 2021 | 2 | |
| 2022 | 2 | |
| 2023 | 2 | |
| 2024 | 1 | |
| 2025 | 1 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #367 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.