Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,258
Total Reports
95
Deaths Reported
760.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 23.3 kg (51.4 lbs)
Top Reported Reactions
Vomiting 219
Lethargy (see also Central nervous system depression in 'Neurological') 122
Emesis 90
Diarrhoea 87
Lack of efficacy - NOS 73
Lack of efficacy (endoparasite) - heartworm 73
Anorexia 61
Lack of efficacy (ectoparasite) - flea 61
INEFFECTIVE, HEARTWORM LARVAE 56
Seizure NOS 53
Death 47
Death by euthanasia 45
Other abnormal test result NOS 44
Not eating 35
Behavioural disorder NOS 32
Most Referenced Drugs
Milbemycin Oxime + Spinosad 218
Oclacitinib Maleate 126
Ivermectin + Pyrantel As Pamoate Salt 97
Afoxolaner 83
Spinosad 81
Moxidectin 65
Pyrantel Pamoate;Sarolaner 48
Carprofen 42
Milbemycin Oxime + Praziquantel 38
Bedinvetmab 34
Fluralaner Chew Tablets 31
Maropitant Citrate 24
Ivermectin 23
Gabapentin 23
Trilostane 22
Outcome Breakdown
Outcome Unknown
390 (33.0%)
Recovered/Normal
336 (28.4%)
Ongoing
316 (26.7%)
Died
57 (4.8%)
Recovered with Sequela
45 (3.8%)
Euthanized
38 (3.2%)
Gender Distribution
Female 616 (49.0%)
Male 612 (48.6%)
Unknown 27 (2.1%)
Mixed 3 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 40 | |
| 2011 | 62 | |
| 2012 | 93 | |
| 2013 | 102 | |
| 2014 | 99 | |
| 2015 | 79 | |
| 2016 | 119 | |
| 2017 | 100 | |
| 2018 | 83 | |
| 2019 | 87 | |
| 2020 | 77 | |
| 2021 | 59 | |
| 2022 | 64 | |
| 2023 | 62 | |
| 2024 | 86 | |
| 2025 | 46 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #97 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.