Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
240
Total Reports
4
Deaths Reported
170.0%
Death Rate
5.8 yr
Avg Age at Report
Average weight at time of report: 21.4 kg (47.2 lbs)
Top Reported Reactions
Vomiting 65
Lack of efficacy (endoparasite) - hookworm 20
Diarrhoea 17
Lethargy (see also Central nervous system depression in 'Neurological') 13
Lack of efficacy - NOS 13
Lack of efficacy (bacteria) - Borrelia 13
Lack of efficacy (ectoparasite) - tick NOS 12
Emesis 10
Lethargy (see also Central nervous system depression in Neurological) 9
INEFFECTIVE, ASCARIDS NOS 8
Lack of efficacy (ectoparasite) - flea 8
INEFFECTIVE, HEARTWORM LARVAE 8
Lack of efficacy (endoparasite) - heartworm 8
Anorexia 7
Digestive tract disorder NOS 7
Most Referenced Drugs
Milbemycin Oxime + Spinosad 37
Ivermectin + Pyrantel As Pamoate Salt 35
Milbemycin Oxime + Praziquantel 21
Afoxolaner 20
Pyrantel Pamoate;Sarolaner 17
Fluralaner Chew Tablets 13
Grapiprant 10
Spinosad 8
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 7
Fluralaner 13.64% 12-Week Chew 7
Bedinvetmab 7
Moxidectin 6
Lotilaner 6
Deracoxib 4
Selamectin 4
Outcome Breakdown
Outcome Unknown
87 (38.3%)
Recovered/Normal
75 (33.0%)
Ongoing
53 (23.3%)
Recovered with Sequela
8 (3.5%)
Died
3 (1.3%)
Euthanized
1 (0.4%)
Gender Distribution
Female 126 (52.5%)
Male 106 (44.2%)
Mixed 5 (2.1%)
Unknown 3 (1.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 11 | |
| 2011 | 3 | |
| 2012 | 7 | |
| 2013 | 10 | |
| 2014 | 16 | |
| 2015 | 15 | |
| 2016 | 26 | |
| 2017 | 18 | |
| 2018 | 22 | |
| 2019 | 17 | |
| 2020 | 15 | |
| 2021 | 12 | |
| 2022 | 11 | |
| 2023 | 22 | |
| 2024 | 22 | |
| 2025 | 13 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #175 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.