Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
210
Total Reports
8
Deaths Reported
380.0%
Death Rate
4.7 yr
Avg Age at Report
Average weight at time of report: 30.1 kg (66.4 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 32
Vomiting 24
Lack of efficacy (endoparasite) - hookworm 20
INEFFECTIVE, HEARTWORM LARVAE 17
Emesis 14
Lethargy (see also Central nervous system depression in 'Neurological') 14
Diarrhoea 13
Decreased appetite 10
Seizure NOS 9
Lack of efficacy (bacteria) - Borrelia 9
Lack of efficacy - NOS 8
Lack of efficacy (endoparasite) - whipworm 8
Lack of efficacy (ectoparasite) - tick NOS 7
Weight loss 6
Other abnormal test result NOS 6
Most Referenced Drugs
Milbemycin Oxime + Spinosad 45
Milbemycin Oxime + Praziquantel 33
Pyrantel Pamoate;Sarolaner 31
Moxidectin 22
Ivermectin + Pyrantel As Pamoate Salt 20
Oclacitinib Maleate 11
Fluralaner 13.64% 12-Week Chew 9
Afoxolaner 8
Carprofen 8
Bedinvetmab 7
Trilostane 6
Enrofloxacin 5
Spinosad 4
Selamectin 4
Sarolaner 4
Outcome Breakdown
Ongoing
83 (39.5%)
Outcome Unknown
59 (28.1%)
Recovered/Normal
48 (22.9%)
Recovered with Sequela
12 (5.7%)
Died
4 (1.9%)
Euthanized
4 (1.9%)
Gender Distribution
Female 108 (51.4%)
Male 100 (47.6%)
Unknown 2 (1.0%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2012 | 5 | |
| 2013 | 12 | |
| 2014 | 13 | |
| 2015 | 7 | |
| 2016 | 11 | |
| 2017 | 20 | |
| 2018 | 8 | |
| 2019 | 12 | |
| 2020 | 12 | |
| 2021 | 21 | |
| 2022 | 16 | |
| 2023 | 34 | |
| 2024 | 28 | |
| 2025 | 11 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #182 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.