Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
535
Total Reports
31
Deaths Reported
580.0%
Death Rate
6.1 yr
Avg Age at Report
Average weight at time of report: 25.8 kg (56.9 lbs)
Top Reported Reactions
Vomiting 90
Diarrhoea 59
Lethargy (see also Central nervous system depression in 'Neurological') 40
Emesis 35
Anorexia 28
Lack of efficacy - NOS 28
Lack of efficacy (endoparasite) - hookworm 24
Other abnormal test result NOS 22
Lack of efficacy (ectoparasite) - flea 21
Lack of efficacy (ectoparasite) - tick NOS 19
Death by euthanasia 18
Emesis (multiple) 18
INEFFECTIVE, HEARTWORM LARVAE 17
Digestive tract disorder NOS 17
Not eating 17
Most Referenced Drugs
Milbemycin Oxime + Spinosad 65
Afoxolaner 45
Ivermectin + Pyrantel As Pamoate Salt 45
Pyrantel Pamoate;Sarolaner 41
Bedinvetmab 26
Fluralaner Chew Tablets 25
Fluralaner 13.64% 12-Week Chew 24
Carprofen 22
Spinosad 18
Milbemycin Oxime + Praziquantel 18
Moxidectin 16
Grapiprant 16
Insulin Injectable Vial 14
Sarolaner 12
Lotilaner 12
Outcome Breakdown
Recovered/Normal
162 (32.5%)
Outcome Unknown
145 (29.1%)
Ongoing
142 (28.5%)
Euthanized
18 (3.6%)
Recovered with Sequela
18 (3.6%)
Died
13 (2.6%)
Gender Distribution
Male 264 (49.3%)
Female 262 (49.0%)
Unknown 8 (1.5%)
Mixed 1 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 19 | |
| 2011 | 35 | |
| 2012 | 27 | |
| 2013 | 32 | |
| 2014 | 28 | |
| 2015 | 35 | |
| 2016 | 30 | |
| 2017 | 40 | |
| 2018 | 42 | |
| 2019 | 39 | |
| 2020 | 36 | |
| 2021 | 40 | |
| 2022 | 23 | |
| 2023 | 39 | |
| 2024 | 45 | |
| 2025 | 25 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #135 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.