Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,525
Total Reports
100
Deaths Reported
400.0%
Death Rate
7.0 yr
Avg Age at Report
Average weight at time of report: 6.6 kg (14.6 lbs)
Top Reported Reactions
Vomiting 593
Emesis 402
Lethargy (see also Central nervous system depression in 'Neurological') 297
Lack of efficacy (ectoparasite) - flea 223
Diarrhoea 173
Seizure NOS 158
Anorexia 115
Lack of efficacy - NOS 109
Pruritus 92
Lack of efficacy (endoparasite) - hookworm 82
Behavioural disorder NOS 79
Not eating 64
Ataxia 63
Other abnormal test result NOS 61
Decreased appetite 59
Most Referenced Drugs
Milbemycin Oxime + Spinosad 636
Spinosad 396
Afoxolaner 144
Ivermectin + Pyrantel As Pamoate Salt 134
Fluralaner Chew Tablets 101
Moxidectin 88
Oclacitinib Maleate 80
Carprofen 67
Fluralaner 13.64% 12-Week Chew 63
Milbemycin Oxime + Praziquantel 57
Pyrantel Pamoate;Sarolaner 57
Sarolaner 56
Nitenpyram 53
Selamectin 50
Imidacloprid + Moxidectin 49
Outcome Breakdown
Recovered/Normal
1,048 (45.5%)
Outcome Unknown
648 (28.1%)
Ongoing
409 (17.7%)
Recovered with Sequela
100 (4.3%)
Died
62 (2.7%)
Euthanized
38 (1.6%)
Gender Distribution
Male 1,303 (51.6%)
Female 1,147 (45.4%)
Unknown 68 (2.7%)
Mixed 7 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 119 | |
| 2011 | 187 | |
| 2012 | 299 | |
| 2013 | 281 | |
| 2014 | 236 | |
| 2015 | 230 | |
| 2016 | 197 | |
| 2017 | 184 | |
| 2018 | 155 | |
| 2019 | 109 | |
| 2020 | 117 | |
| 2021 | 105 | |
| 2022 | 84 | |
| 2023 | 71 | |
| 2024 | 101 | |
| 2025 | 50 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #70 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.