Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
26
Total Reports
3
Deaths Reported
1150.0%
Death Rate
5.4 yr
Avg Age at Report
Average weight at time of report: 24.6 kg (54.2 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 9
Lack of efficacy (endoparasite) - roundworm NOS 3
Weight loss 3
Increased appetite 2
Loose stool 2
Frequent urination 2
Elevated serum alkaline phosphatase (ALP) 2
Death by euthanasia 2
Weight gain 2
High sodium-potassium ratio (Na:K ratio) 2
Vomiting 2
Itching 2
Lack of efficacy (ectoparasite) - flea 2
Lack of efficacy - NOS 1
Elevated alanine aminotransferase (ALT) 1
Most Referenced Drugs
Milbemycin Oxime + Praziquantel 7
Milbemycin/Lufenuron Tablets 6
Ivermectin + Pyrantel 4
Fluralaner 13.64% 12-Week Chew 4
Trilostane 3
Fluids 3
Afoxolaner 2
Desoxycortone Pivalate 2
Prednisolone 2
Milbemycin Oxime, Praziquantel 1
Estriol Tablets 1
Canine Lepto*4(Orig S-P Us) Kb 1
Potassium Chloride 1
Lotilaner 1
Sarolaner,Moxidectin,Pyrantel 1
Outcome Breakdown
Ongoing
14 (53.8%)
Outcome Unknown
6 (23.1%)
Recovered/Normal
3 (11.5%)
Euthanized
2 (7.7%)
Died
1 (3.8%)
Gender Distribution
Male 17 (65.4%)
Female 9 (34.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2022 | 1 | |
| 2023 | 4 | |
| 2024 | 14 | |
| 2025 | 7 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #337 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.