Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
8,853
Total Reports
439
Deaths Reported
500.0%
Death Rate
5.9 yr
Avg Age at Report
Average weight at time of report: 5.2 kg (11.5 lbs)
Top Reported Reactions
Vomiting 2,084
Lethargy (see also Central nervous system depression in 'Neurological') 1,072
Lack of efficacy (ectoparasite) - flea 963
Emesis 929
Diarrhoea 676
Seizure NOS 534
Anorexia 385
Lack of efficacy - NOS 368
Death 276
Behavioural disorder NOS 262
Ataxia 258
Lack of efficacy (endoparasite) - hookworm 244
Shaking 236
Not eating 232
Emesis (multiple) 230
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,770
Spinosad 1,240
Afoxolaner 565
Ivermectin + Pyrantel As Pamoate Salt 495
Fluralaner Chew Tablets 411
Pyrantel Pamoate;Sarolaner 411
Moxidectin 346
Fluralaner 13.64% 12-Week Chew 303
Nitenpyram 254
Selamectin 211
Milbemycin Oxime + Praziquantel 208
Sarolaner 203
Imidacloprid + Moxidectin 175
Maropitant Citrate 155
Oclacitinib Maleate 141
Outcome Breakdown
Recovered/Normal
3,173 (38.9%)
Outcome Unknown
2,527 (31.0%)
Ongoing
1,696 (20.8%)
Recovered with Sequela
325 (4.0%)
Died
308 (3.8%)
Euthanized
131 (1.6%)
Gender Distribution
Male 4,463 (50.4%)
Female 4,159 (47.0%)
Unknown 200 (2.3%)
Mixed 31 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 387 | |
| 2011 | 510 | |
| 2012 | 766 | |
| 2013 | 785 | |
| 2014 | 759 | |
| 2015 | 691 | |
| 2016 | 661 | |
| 2017 | 680 | |
| 2018 | 576 | |
| 2019 | 555 | |
| 2020 | 455 | |
| 2021 | 455 | |
| 2022 | 374 | |
| 2023 | 408 | |
| 2024 | 479 | |
| 2025 | 312 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #23 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.