Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
468
Total Reports
19
Deaths Reported
410.0%
Death Rate
5.0 yr
Avg Age at Report
Average weight at time of report: 26.8 kg (59.1 lbs)
Top Reported Reactions
Vomiting 74
Lack of efficacy (endoparasite) - heartworm 61
Lack of efficacy (endoparasite) - hookworm 46
Digestive tract disorder NOS 30
Lack of efficacy (ectoparasite) - tick NOS 27
INEFFECTIVE, HEARTWORM LARVAE 26
Diarrhoea 19
Lack of efficacy (bacteria) - Borrelia 19
Lack of efficacy (bacteria) - NOS 18
INEFFECTIVE, ASCARIDS NOS 17
Lethargy (see also Central nervous system depression in 'Neurological') 16
Lack of efficacy (endoparasite) - roundworm NOS 16
Lack of efficacy - NOS 15
Seizure NOS 12
Emesis 12
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 97
Milbemycin Oxime + Praziquantel 43
Afoxolaner 42
Pyrantel Pamoate;Sarolaner 41
Moxidectin 35
Milbemycin Oxime + Spinosad 29
Fluralaner Chew Tablets 18
Fluralaner 13.64% 12-Week Chew 18
Lotilaner 14
Carprofen 12
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 11
Oclacitinib Maleate 11
Sarolaner 11
Lufenuron + Milbemycin Oxime 9
Bedinvetmab 9
Outcome Breakdown
Outcome Unknown
162 (35.3%)
Ongoing
150 (32.7%)
Recovered/Normal
106 (23.1%)
Recovered with Sequela
22 (4.8%)
Euthanized
11 (2.4%)
Died
8 (1.7%)
Gender Distribution
Male 256 (54.7%)
Female 206 (44.0%)
Unknown 4 (0.9%)
Mixed 2 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 2 | |
| 2011 | 8 | |
| 2012 | 12 | |
| 2013 | 19 | |
| 2014 | 16 | |
| 2015 | 27 | |
| 2016 | 43 | |
| 2017 | 30 | |
| 2018 | 30 | |
| 2019 | 45 | |
| 2020 | 38 | |
| 2021 | 41 | |
| 2022 | 41 | |
| 2023 | 41 | |
| 2024 | 46 | |
| 2025 | 29 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #142 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.