Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
215
Total Reports
4
Deaths Reported
190.0%
Death Rate
5.1 yr
Avg Age at Report
Average weight at time of report: 11.5 kg (25.4 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 65
INEFFECTIVE, HEARTWORM LARVAE 41
Cardiac disorder NOS 24
Vomiting 17
Lack of efficacy (endoparasite) - hookworm 17
Lack of efficacy - NOS 16
Emesis 14
Lack of efficacy (ectoparasite) - flea 14
Digestive tract disorder NOS 11
Lethargy (see also Central nervous system depression in 'Neurological') 10
Diarrhoea 9
Underdose 7
Lack of efficacy (ectoparasite) - tick NOS 6
Weight gain 5
Not eating 5
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 104
Milbemycin Oxime + Spinosad 39
Afoxolaner 24
Milbemycin Oxime + Praziquantel 19
Spinosad 10
Lotilaner 8
Nitenpyram 7
Moxidectin 6
Melarsomine Dihydrochloride 4
Ivermectin 3
Fluralaner 3
Recombitek Lyme - 2126.R0 3
Ivermectin/Pyrantel Chew. Dog 68Mcg/57Mg 2
Ivermectin/Pyrantel Pamoate Chewable 136Mcg/326Mg 2
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 2
Outcome Breakdown
Outcome Unknown
112 (52.1%)
Recovered with Sequela
48 (22.3%)
Recovered/Normal
34 (15.8%)
Ongoing
17 (7.9%)
Died
2 (0.9%)
Euthanized
2 (0.9%)
Gender Distribution
Female 110 (51.2%)
Male 104 (48.4%)
Unknown 1 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2011 | 2 | |
| 2012 | 8 | |
| 2013 | 19 | |
| 2014 | 9 | |
| 2015 | 18 | |
| 2016 | 15 | |
| 2017 | 23 | |
| 2018 | 15 | |
| 2019 | 21 | |
| 2020 | 17 | |
| 2021 | 27 | |
| 2022 | 14 | |
| 2023 | 10 | |
| 2024 | 10 | |
| 2025 | 7 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #181 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.