Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,084
Total Reports
164
Deaths Reported
400.0%
Death Rate
6.2 yr
Avg Age at Report
Average weight at time of report: 4.5 kg (9.9 lbs)
Top Reported Reactions
Vomiting 1,135
Lethargy (see also Central nervous system depression in 'Neurological') 554
Emesis 444
Diarrhoea 325
Lack of efficacy (ectoparasite) - flea 305
Seizure NOS 239
Lack of efficacy - NOS 181
Anorexia 162
Lack of efficacy (endoparasite) - hookworm 148
Behavioural disorder NOS 147
Not eating 133
Other abnormal test result NOS 118
Shaking 114
Emesis (multiple) 110
Ataxia 97
Most Referenced Drugs
Milbemycin Oxime + Spinosad 865
Ivermectin + Pyrantel As Pamoate Salt 331
Afoxolaner 322
Spinosad 223
Pyrantel Pamoate;Sarolaner 189
Fluralaner Chew Tablets 160
Moxidectin 142
Fluralaner 13.64% 12-Week Chew 121
Oclacitinib Maleate 118
Imidacloprid + Moxidectin 105
Selamectin 97
Sarolaner 96
Milbemycin Oxime + Praziquantel 90
Afoxolaner 28.3 Mg Chewable Tablets 81
Trilostane 79
Outcome Breakdown
Recovered/Normal
1,777 (43.5%)
Outcome Unknown
1,225 (30.0%)
Ongoing
813 (19.9%)
Recovered with Sequela
105 (2.6%)
Died
98 (2.4%)
Euthanized
67 (1.6%)
Gender Distribution
Female 2,162 (52.9%)
Male 1,828 (44.8%)
Unknown 83 (2.0%)
Mixed 11 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 5 | |
| 2011 | 95 | |
| 2012 | 287 | |
| 2013 | 424 | |
| 2014 | 391 | |
| 2015 | 425 | |
| 2016 | 387 | |
| 2017 | 359 | |
| 2018 | 290 | |
| 2019 | 263 | |
| 2020 | 217 | |
| 2021 | 236 | |
| 2022 | 177 | |
| 2023 | 165 | |
| 2024 | 216 | |
| 2025 | 147 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #49 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.