Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
218
Total Reports
1
Deaths Reported
50.0%
Death Rate
4.4 yr
Avg Age at Report
Average weight at time of report: 26.1 kg (57.6 lbs)
Top Reported Reactions
Vomiting 39
Lack of efficacy (endoparasite) - hookworm 24
Diarrhoea 21
Digestive tract disorder NOS 20
Lethargy (see also Central nervous system depression in 'Neurological') 19
Lack of efficacy (endoparasite) - heartworm 12
INEFFECTIVE, ASCARIDS NOS 11
Lack of efficacy (ectoparasite) - tick NOS 11
Lack of efficacy (bacteria) - NOS 11
INEFFECTIVE, HOOKS 10
Lack of efficacy (endoparasite) - roundworm NOS 10
INEFFECTIVE, HEARTWORM LARVAE 7
Decreased appetite 7
Other abnormal test result NOS 7
Seizure NOS 6
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 40
Afoxolaner 23
Milbemycin Oxime + Spinosad 20
Pyrantel Pamoate;Sarolaner 20
Fluralaner Chew Tablets 16
Milbemycin Oxime + Praziquantel 13
Bedinvetmab 11
Fluralaner 13.64% 12-Week Chew 9
Sarolaner 8
Moxidectin 6
Fluralaner 5.46% 1-Month Chew 5
Spinosad, Milbemycin 4
Fluoxetine 4
Lufenuron + Milbemycin Oxime 4
Grapiprant 4
Outcome Breakdown
Outcome Unknown
78 (37.7%)
Ongoing
68 (32.9%)
Recovered/Normal
54 (26.1%)
Recovered with Sequela
6 (2.9%)
Died
1 (0.5%)
Gender Distribution
Male 111 (50.9%)
Female 105 (48.2%)
Mixed 1 (0.5%)
Unknown 1 (0.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 4 | |
| 2011 | 9 | |
| 2012 | 8 | |
| 2013 | 9 | |
| 2014 | 7 | |
| 2015 | 13 | |
| 2016 | 11 | |
| 2017 | 23 | |
| 2018 | 15 | |
| 2019 | 13 | |
| 2020 | 9 | |
| 2021 | 12 | |
| 2022 | 13 | |
| 2023 | 34 | |
| 2024 | 22 | |
| 2025 | 16 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #180 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.