Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,480
Total Reports
113
Deaths Reported
460.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 32.3 kg (71.2 lbs)
Top Reported Reactions
Vomiting 403
INEFFECTIVE, HEARTWORM LARVAE 250
Lethargy (see also Central nervous system depression in 'Neurological') 211
Diarrhoea 187
Emesis 179
Lack of efficacy (endoparasite) - heartworm 171
Lack of efficacy - NOS 160
Lack of efficacy (endoparasite) - hookworm 157
Digestive tract disorder NOS 115
Anorexia 89
Seizure NOS 81
INEFFECTIVE, ASCARIDS NOS 76
Ataxia 75
Death by euthanasia 66
Other abnormal test result NOS 65
Most Referenced Drugs
Milbemycin Oxime + Spinosad 419
Ivermectin + Pyrantel As Pamoate Salt 300
Moxidectin 165
Afoxolaner 110
Milbemycin Oxime + Praziquantel 109
Carprofen 108
Pyrantel Pamoate;Sarolaner 106
Spinosad 90
Fluralaner Chew Tablets 80
Bedinvetmab 73
Oclacitinib Maleate 68
Ivermectin, Pyrantel 65
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 62
Milbemycin Oxime 46
Melarsomine Dihydrochloride 44
Outcome Breakdown
Outcome Unknown
754 (33.8%)
Recovered/Normal
643 (28.8%)
Ongoing
593 (26.6%)
Recovered with Sequela
128 (5.7%)
Euthanized
63 (2.8%)
Died
50 (2.2%)
Gender Distribution
Female 1,226 (49.4%)
Male 1,193 (48.1%)
Unknown 50 (2.0%)
Mixed 11 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 146 | |
| 2011 | 147 | |
| 2012 | 203 | |
| 2013 | 193 | |
| 2014 | 170 | |
| 2015 | 185 | |
| 2016 | 176 | |
| 2017 | 166 | |
| 2018 | 190 | |
| 2019 | 172 | |
| 2020 | 150 | |
| 2021 | 106 | |
| 2022 | 117 | |
| 2023 | 119 | |
| 2024 | 148 | |
| 2025 | 92 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #71 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.