Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
7,270
Total Reports
346
Deaths Reported
480.0%
Death Rate
3.9 yr
Avg Age at Report
Average weight at time of report: 25.5 kg (56.2 lbs)
Top Reported Reactions
Vomiting 1,582
Emesis 945
Lethargy (see also Central nervous system depression in 'Neurological') 732
Diarrhoea 568
Lack of efficacy - NOS 414
Lack of efficacy (ectoparasite) - flea 355
Seizure NOS 329
Lack of efficacy (endoparasite) - heartworm 290
INEFFECTIVE, HEARTWORM LARVAE 258
Death 218
Anorexia 210
Hives (see also 'Skin') 200
Emesis (multiple) 177
Lack of efficacy (endoparasite) - hookworm 175
Other abnormal test result NOS 159
Most Referenced Drugs
Milbemycin Oxime + Spinosad 1,805
Oclacitinib Maleate 617
Spinosad 545
Ivermectin + Pyrantel As Pamoate Salt 527
Afoxolaner 423
Moxidectin 411
Fluralaner Chew Tablets 401
Pyrantel Pamoate;Sarolaner 217
Carprofen 200
Milbemycin Oxime + Praziquantel 175
Cyclosporine 140
Sarolaner 134
Fluralaner 13.64% 12-Week Chew 127
Imidacloprid + Moxidectin 123
Anti-Il31 Mab Mcs Lot #1283563 123
Outcome Breakdown
Recovered/Normal
2,660 (39.5%)
Outcome Unknown
1,852 (27.5%)
Ongoing
1,616 (24.0%)
Recovered with Sequela
256 (3.8%)
Died
250 (3.7%)
Euthanized
96 (1.4%)
Gender Distribution
Male 3,923 (54.0%)
Female 3,132 (43.1%)
Unknown 189 (2.6%)
Mixed 26 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 294 | |
| 2011 | 457 | |
| 2012 | 651 | |
| 2013 | 591 | |
| 2014 | 589 | |
| 2015 | 650 | |
| 2016 | 656 | |
| 2017 | 606 | |
| 2018 | 566 | |
| 2019 | 538 | |
| 2020 | 499 | |
| 2021 | 446 | |
| 2022 | 400 | |
| 2023 | 327 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #30 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.