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2026 FDA CVM data 7,270 reports on file official source

Bulldog — FDA Adverse Event Profile

Adverse-event records and label data for Bulldog (Dog), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.

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Annual breed adverse-event registration timeline Bar chart showing yearly FDA Center for Veterinary Medicine adverse event report counts per breed registry cohort, with paw-print tick marks indicating count buckets. 656 492 328 164 0 2016 2017 2018 2019 2020 2021 2022 2023 Reports filed Death-coded reports
Annual report volume for Bulldog drawn from FDA CVM filings.

Bulldog (Dog) has 7,270 FDA adverse event reports on record, with 346 deaths reported (480.0% death rate) — ranking #30 by report volume. The most frequently reported reaction is Vomiting (1,582 cases). The top associated drug is Milbemycin Oxime + Spinosad. Average age at report: 3.9 years.

Total Reports

7,270

FDA CVM filings

Deaths Reported

346

of 7,270 reports

Death Rate

480.0%

death-coded share

Avg Age at Report

3.9 yr

25.5 kg avg weight

Death-Coded Outcome Share

Bulldog death-coded reports 100.0%
Database median

480.0% of 7,270 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.

Average weight at time of report: 25.5 kg (56.2 lbs)

Top Reported Reactions

Vomiting 1,582
Emesis 945
Lethargy (see also Central nervous system depression in 'Neurological') 732
Diarrhoea 568
Lack of efficacy - NOS 414
Lack of efficacy (ectoparasite) - flea 355
Seizure NOS 329
Lack of efficacy (endoparasite) - heartworm 290
INEFFECTIVE, HEARTWORM LARVAE 258
Death 218
Anorexia 210
Hives (see also 'Skin') 200
Emesis (multiple) 177
Lack of efficacy (endoparasite) - hookworm 175
Other abnormal test result NOS 159

Most Referenced Drugs

Milbemycin Oxime + Spinosad 1,805
Oclacitinib Maleate 617
Spinosad 545
Ivermectin + Pyrantel As Pamoate Salt 527
Afoxolaner 423
Moxidectin 411
Fluralaner Chew Tablets 401
Pyrantel Pamoate;Sarolaner 217
Carprofen 200
Milbemycin Oxime + Praziquantel 175
Cyclosporine 140
Sarolaner 134
Fluralaner 13.64% 12-Week Chew 127
Imidacloprid + Moxidectin 123
Anti-Il31 Mab Mcs Lot #1283563 123

Outcome Breakdown

Recovered/Normal
2,660 (39.5%)
Outcome Unknown
1,852 (27.5%)
Ongoing
1,616 (24.0%)
Recovered with Sequela
256 (3.8%)
Died
250 (3.7%)
Euthanized
96 (1.4%)

Gender Distribution

Male 3,923 (54.0%)
Female 3,132 (43.1%)
Unknown 189 (2.6%)
Mixed 26 (0.4%)

Reports by Year

Year Reports Trend
2010 294
2011 457
2012 651
2013 591
2014 589
2015 650
2016 656
2017 606
2018 566
2019 538
2020 499
2021 446
2022 400
2023 327
Size-class weight distribution across registered breeds Vertical bar chart showing the distribution of registered breeds across five size classes (Toy, Small, Medium, Large, Giant), each represented by a scaled dog-silhouette and a count value. 118 89 59 30 0 Breeds in class 38 Toy 0–6 kg Chihuahua 64 Small 6–14 kg Beagle 92 Medium 14–27 kg Border Collie 118 Large 27–45 kg Labrador Retriever 41 Giant 45–90 kg Great Dane Size-Class Distribution
Where Bulldog sits in the registered size-class taxonomy. Average reported weight: 25.5 kg.
Breed-group distribution donut chart Donut chart with kennel-club-ribbon center showing breed counts across the eight standard breed groups (Sporting, Hound, Working, Terrier, Toy, Non-Sporting, Herding, Miscellaneous). CH Sporting 32 · 14.2% Hound 36 · 15.9% Working 33 · 14.6% Terrier 31 · 13.7% Toy 23 · 10.2% Non-Sporting 21 · 9.3% Herding 32 · 14.2% Misc. 18 · 8.0% Breed-Group Classification 226 breeds across 8 taxonomic groups
Eight standard breed-group classifications used by major registries (AKC's seven groups plus Miscellaneous). Provides taxonomic context for breed lookups.

Bulldog Pet Health Insights

Across the FDA Center for Veterinary Medicine adverse event database, Bulldog accounts for 7,270 submitted reports and currently ranks #30 by report volume within the dog population. Of those reports, 346 involved a death outcome — a 480.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 3.9 years, with an average recorded body weight of 25.5 kg (56.2 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.

The most frequently reported clinical signs for Bulldog are Vomiting (1,582 reports), Emesis (945 reports), Lethargy (see also Central nervous system depression in 'Neurological') (732 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Milbemycin Oxime + Spinosad appears in 1,805 reports and is the single most-referenced drug, followed by Oclacitinib Maleate (617) and Spinosad (545). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same dog species.

Outcome coding on the 6,730 reports with a recorded status is dominated by Recovered/Normal (39.5% of coded outcomes). Annual submission volume ranges from 2,010 to 2,023 reports across the 14 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual dog.

Understanding Bulldog Adverse Event Data

With 7,270 adverse event reports, Bulldog has one of the larger report volumes in the FDA database. This typically reflects breed popularity rather than inherent health risk — more pets of a breed means more veterinary encounters and more opportunity for adverse event reporting.

The 480.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.

The most frequently referenced drug in adverse reports is Milbemycin Oxime + Spinosad, appearing in 1,805 reports. This may indicate widespread use of the medication rather than a specific safety concern for Bulldog.

Other Dog Breeds

Frequently Asked Questions

How many FDA adverse event reports involve Bulldog?
There are 7,270 adverse event reports involving Bulldog in the FDA database, with 346 reports involving death (480.0% death rate). Bulldog ranks #30 by report volume.
What are the most common adverse reactions reported for Bulldog?
The most commonly reported adverse reactions for Bulldog are Vomiting (1,582 reports), Emesis (945 reports), Lethargy (see also Central nervous system depression in 'Neurological') (732 reports), Diarrhoea (568 reports), Lack of efficacy - NOS (414 reports).
What drugs are most frequently associated with Bulldog adverse events?
The drugs most frequently referenced in Bulldog adverse event reports are Milbemycin Oxime + Spinosad (1,805 reports), Oclacitinib Maleate (617 reports), Spinosad (545 reports), Ivermectin + Pyrantel As Pamoate Salt (527 reports), Afoxolaner (423 reports).
What is the average age of Bulldog in adverse event reports?
The average age of Bulldog at the time of adverse event reports is 3.9 years, with an average weight of 25.5 kg (56.2 lbs).
Does a high number of adverse event reports mean Bulldog is unhealthy?
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Bulldog safety data come from?
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.

Guides & Resources

Related Data Sources

Data Sources & Methodology

Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.

Bulldog ranks #30 by total report volume. Death rate (480.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.

Related

Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial