Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
704
Total Reports
11
Deaths Reported
160.0%
Death Rate
4.3 yr
Avg Age at Report
Average weight at time of report: 16.7 kg (36.8 lbs)
Top Reported Reactions
Lack of efficacy (endoparasite) - heartworm 140
Vomiting 126
Lack of efficacy (endoparasite) - hookworm 66
INEFFECTIVE, HEARTWORM LARVAE 54
Emesis 42
Lethargy (see also Central nervous system depression in 'Neurological') 39
Lack of efficacy - NOS 35
Diarrhoea 30
INEFFECTIVE, HOOKS 22
Seizure NOS 18
Lack of efficacy (ectoparasite) - tick NOS 18
Lack of efficacy (ectoparasite) - flea 17
Cardiac disorder NOS 16
Digestive tract disorder NOS 16
Lack of efficacy (endoparasite) - roundworm NOS 15
Most Referenced Drugs
Milbemycin Oxime + Spinosad 143
Ivermectin + Pyrantel As Pamoate Salt 122
Moxidectin 85
Pyrantel Pamoate;Sarolaner 58
Milbemycin Oxime + Praziquantel 53
Afoxolaner 43
Spinosad 30
Oclacitinib Maleate 21
Fluralaner Chew Tablets 20
Fluralaner 13.64% 12-Week Chew 18
Sarolaner 17
Ivermectin 14
Ivermectin + Pyrantel 13
Bedinvetmab 13
Melarsomine Dihydrochloride 11
Outcome Breakdown
Outcome Unknown
227 (34.2%)
Ongoing
218 (32.8%)
Recovered/Normal
174 (26.2%)
Recovered with Sequela
34 (5.1%)
Euthanized
7 (1.1%)
Died
4 (0.6%)
Gender Distribution
Male 363 (51.6%)
Female 333 (47.3%)
Unknown 7 (1.0%)
Mixed 1 (0.1%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 21 | |
| 2011 | 31 | |
| 2012 | 33 | |
| 2013 | 32 | |
| 2014 | 28 | |
| 2015 | 35 | |
| 2016 | 41 | |
| 2017 | 42 | |
| 2018 | 42 | |
| 2019 | 47 | |
| 2020 | 48 | |
| 2021 | 48 | |
| 2022 | 63 | |
| 2023 | 68 | |
| 2024 | 65 | |
| 2025 | 60 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #121 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.