Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
176
Total Reports
4
Deaths Reported
230.0%
Death Rate
5.5 yr
Avg Age at Report
Average weight at time of report: 16.4 kg (36.2 lbs)
Top Reported Reactions
Vomiting 39
Lethargy (see also Central nervous system depression in 'Neurological') 15
Emesis 12
Lack of efficacy - NOS 11
Lack of efficacy (endoparasite) - heartworm 11
Diarrhoea 10
Lack of efficacy (ectoparasite) - tick NOS 7
Digestive tract disorder NOS 6
Lack of efficacy (endoparasite) - hookworm 6
Behavioural disorder NOS 6
Not eating 6
Fever 5
Anorexia 5
Elevated alanine aminotransferase (ALT) 5
Decreased appetite 5
Most Referenced Drugs
Ivermectin + Pyrantel As Pamoate Salt 24
Spinosad 18
Pyrantel Pamoate;Sarolaner 18
Milbemycin Oxime + Spinosad 13
Oclacitinib Maleate 12
Fluralaner Chew Tablets 12
Milbemycin Oxime + Praziquantel 10
Afoxolaner 9
Carprofen 7
Fluralaner 13.64% 12-Week Chew 5
Cyclosporine A 4
Ivermectin 4
Moxidectin 4
Selamectin 3
Afoxolaner 68 Mg Chewable Tablets 3
Outcome Breakdown
Recovered/Normal
65 (39.2%)
Outcome Unknown
47 (28.3%)
Ongoing
43 (25.9%)
Recovered with Sequela
7 (4.2%)
Died
3 (1.8%)
Euthanized
1 (0.6%)
Gender Distribution
Male 98 (55.7%)
Female 77 (43.8%)
Unknown 1 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 7 | |
| 2011 | 8 | |
| 2012 | 11 | |
| 2013 | 5 | |
| 2014 | 10 | |
| 2015 | 13 | |
| 2016 | 18 | |
| 2017 | 12 | |
| 2018 | 20 | |
| 2019 | 10 | |
| 2020 | 15 | |
| 2021 | 15 | |
| 2022 | 10 | |
| 2023 | 8 | |
| 2024 | 8 | |
| 2025 | 6 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #191 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.