Total Reports
1,124
FDA CVM filings
Dog /
2026 FDA CVM data 1,124 reports on file official source
Spitz - American Eskimo Dog — FDA Adverse Event Profile
Adverse-event records and label data for Spitz - American Eskimo Dog (Dog), sourced from the FDA Center for Veterinary Medicine. Refreshed as new reports are filed. Cite PlainBreed when reusing this analysis.
Spitz - American Eskimo Dog (Dog) has 1,124 FDA adverse event reports on record, with 52 deaths reported (460.0% death rate) — ranking #105 by report volume. The most frequently reported reaction is Vomiting (274 cases). The top associated drug is Milbemycin Oxime + Spinosad. Average age at report: 7.2 years.
Deaths Reported
52
of 1,124 reports
Death Rate
460.0%
death-coded share
Avg Age at Report
7.2 yr
11.6 kg avg weight
Death-Coded Outcome Share
Spitz - American Eskimo Dog death-coded reports 100.0%
Database median
460.0% of 1,124 reports involved a death outcome. Read alongside breed popularity, veterinary access, and owner awareness — these shape how many events ever reach the FDA. The 12% comparison line is the rough cross-breed median in the FDA CVM database; values above suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 11.6 kg (25.6 lbs)
Top Reported Reactions
Vomiting 274
Lethargy (see also Central nervous system depression in 'Neurological') 118
Diarrhoea 101
Emesis 101
Lack of efficacy (ectoparasite) - flea 74
Seizure NOS 68
Lack of efficacy - NOS 51
Lack of efficacy (endoparasite) - hookworm 47
Anorexia 47
Digestive tract disorder NOS 38
Behavioural disorder NOS 35
INEFFECTIVE, HEARTWORM LARVAE 31
Elevated blood urea nitrogen (BUN) 29
Ataxia 27
Emesis (multiple) 25
Most Referenced Drugs
Milbemycin Oxime + Spinosad 192
Spinosad 96
Afoxolaner 89
Ivermectin + Pyrantel As Pamoate Salt 83
Fluralaner Chew Tablets 53
Trilostane 45
Moxidectin 39
Carprofen 33
Sarolaner 33
Pyrantel Pamoate;Sarolaner 33
Milbemycin Oxime + Praziquantel 31
Fluralaner 13.64% 12-Week Chew 27
Bedinvetmab 22
Selamectin 21
Imidacloprid + Moxidectin 17
Outcome Breakdown
Recovered/Normal
389 (38.4%)
Outcome Unknown
328 (32.3%)
Ongoing
200 (19.7%)
Recovered with Sequela
45 (4.4%)
Died
26 (2.6%)
Euthanized
26 (2.6%)
Gender Distribution
Male 557 (49.6%)
Female 549 (48.8%)
Unknown 16 (1.4%)
Mixed 2 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 66 | |
| 2011 | 74 | |
| 2012 | 91 | |
| 2013 | 97 | |
| 2014 | 93 | |
| 2015 | 95 | |
| 2016 | 80 | |
| 2017 | 78 | |
| 2018 | 69 | |
| 2019 | 82 | |
| 2020 | 78 | |
| 2021 | 54 | |
| 2022 | 35 | |
| 2023 | 43 | |
| 2024 | 59 | |
| 2025 | 30 | |
Spitz - American Eskimo Dog Pet Health Insights
Across the FDA Center for Veterinary Medicine adverse event database, Spitz - American Eskimo Dog accounts for 1,124 submitted reports and currently ranks #105 by report volume within the dog population. Of those reports, 52 involved a death outcome — a 460.0% case-fatality figure calculated directly from the underlying FDA records rather than from external mortality studies. The mean age at time of reporting is 7.2 years, with an average recorded body weight of 11.6 kg (25.6 lbs). These figures reflect the voluntary reporting pool only and should be read alongside breed popularity, veterinary access, and owner awareness — all of which shape how many events ever reach the FDA.
The most frequently reported clinical signs for Spitz - American Eskimo Dog are Vomiting (274 reports), Lethargy (see also Central nervous system depression in 'Neurological') (118 reports), Diarrhoea (101 reports), together capturing a substantial share of the top-reaction traffic seen in this breed's record. On the product side, Milbemycin Oxime + Spinosad appears in 192 reports and is the single most-referenced drug, followed by Spinosad (96) and Afoxolaner (89). Counts like these surface which therapeutic classes dominate the reporting stream — useful context when comparing reactions across breeds of the same dog species.
Outcome coding on the 1,014 reports with a recorded status is dominated by Recovered/Normal (38.4% of coded outcomes). Annual submission volume ranges from 2,010 to 2,025 reports across the 16 years on file, indicating the reporting trend is shaped as much by awareness cycles as by underlying clinical events. Because FDA adverse event reports describe correlation rather than causation, these numbers are most useful as a signal of where to ask further questions with a veterinarian — not as a standalone risk score for any individual dog.
Understanding Spitz - American Eskimo Dog Adverse Event Data
Spitz - American Eskimo Dog has a moderate volume of adverse event reports (1,124). Report counts are influenced by breed popularity, owner awareness, and veterinary reporting practices.
The 460.0% death rate is above average, though this statistic should be interpreted cautiously. Death reports may be overrepresented because serious outcomes are more likely to be reported than mild reactions.
The most frequently referenced drug in adverse reports is Milbemycin Oxime + Spinosad, appearing in 192 reports. This may indicate widespread use of the medication rather than a specific safety concern for Spitz - American Eskimo Dog.
Other Dog Breeds
Retriever - Labrador
90,806 reports · 360.0% death rate
Crossbred Canine/dog
68,210 reports · 320.0% death rate
Dog (unknown)
47,381 reports · 870.0% death rate
Retriever - Golden
34,475 reports · 370.0% death rate
Shepherd Dog - German
31,142 reports · 430.0% death rate
Chihuahua
30,657 reports · 420.0% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Spitz - American Eskimo Dog? ▼
There are 1,124 adverse event reports involving Spitz - American Eskimo Dog in the FDA database, with 52 reports involving death (460.0% death rate). Spitz - American Eskimo Dog ranks #105 by report volume.
What are the most common adverse reactions reported for Spitz - American Eskimo Dog? ▼
The most commonly reported adverse reactions for Spitz - American Eskimo Dog are Vomiting (274 reports), Lethargy (see also Central nervous system depression in 'Neurological') (118 reports), Diarrhoea (101 reports), Emesis (101 reports), Lack of efficacy (ectoparasite) - flea (74 reports).
What drugs are most frequently associated with Spitz - American Eskimo Dog adverse events? ▼
The drugs most frequently referenced in Spitz - American Eskimo Dog adverse event reports are Milbemycin Oxime + Spinosad (192 reports), Spinosad (96 reports), Afoxolaner (89 reports), Ivermectin + Pyrantel As Pamoate Salt (83 reports), Fluralaner Chew Tablets (53 reports).
What is the average age of Spitz - American Eskimo Dog in adverse event reports? ▼
The average age of Spitz - American Eskimo Dog at the time of adverse event reports is 7.2 years, with an average weight of 11.6 kg (25.6 lbs).
Does a high number of adverse event reports mean Spitz - American Eskimo Dog is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Spitz - American Eskimo Dog safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Guides & Resources
Understanding Adverse Events
What FDA reports are and how they are collected
Breed-Specific Risks
Why some breeds appear in more adverse event reports
Pet Medication Safety
Evaluating medication risks using FDA data
Most Reported Medications
Drugs that appear most in adverse event reports
How FDA CVM Tracks Events
The reporting process and database limitations
Related Data Sources
Data Sources & Methodology
Adverse event data sourced from the FDA Center for Veterinary Medicine via the openFDA Animal & Veterinary Adverse Events API. Reports are voluntarily submitted by pet owners, veterinarians, and product manufacturers.
Spitz - American Eskimo Dog ranks #105 by total report volume. Death rate (460.0%) reflects the proportion of reports involving death and should not be interpreted as a breed-specific mortality rate. Reporting biases, breed popularity, and veterinary access all influence report counts.
Read our methodology — how this data is sourced, computed, and verified.
Related
Data sourced from official AKC, AVMA, ACVO, and breed-club veterinary references. See our methodology for details. Retrieved and formatted by PlainBreed Editorial