Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,124
Total Reports
52
Deaths Reported
460.0%
Death Rate
7.2 yr
Avg Age at Report
Average weight at time of report: 11.6 kg (25.6 lbs)
Top Reported Reactions
Vomiting 274
Lethargy (see also Central nervous system depression in 'Neurological') 118
Diarrhoea 101
Emesis 101
Lack of efficacy (ectoparasite) - flea 74
Seizure NOS 68
Lack of efficacy - NOS 51
Lack of efficacy (endoparasite) - hookworm 47
Anorexia 47
Digestive tract disorder NOS 38
Behavioural disorder NOS 35
INEFFECTIVE, HEARTWORM LARVAE 31
Elevated blood urea nitrogen (BUN) 29
Ataxia 27
Emesis (multiple) 25
Most Referenced Drugs
Milbemycin Oxime + Spinosad 192
Spinosad 96
Afoxolaner 89
Ivermectin + Pyrantel As Pamoate Salt 83
Fluralaner Chew Tablets 53
Trilostane 45
Moxidectin 39
Carprofen 33
Sarolaner 33
Pyrantel Pamoate;Sarolaner 33
Milbemycin Oxime + Praziquantel 31
Fluralaner 13.64% 12-Week Chew 27
Bedinvetmab 22
Selamectin 21
Imidacloprid + Moxidectin 17
Outcome Breakdown
Recovered/Normal
389 (38.4%)
Outcome Unknown
328 (32.3%)
Ongoing
200 (19.7%)
Recovered with Sequela
45 (4.4%)
Died
26 (2.6%)
Euthanized
26 (2.6%)
Gender Distribution
Male 557 (49.6%)
Female 549 (48.8%)
Unknown 16 (1.4%)
Mixed 2 (0.2%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 66 | |
| 2011 | 74 | |
| 2012 | 91 | |
| 2013 | 97 | |
| 2014 | 93 | |
| 2015 | 95 | |
| 2016 | 80 | |
| 2017 | 78 | |
| 2018 | 69 | |
| 2019 | 82 | |
| 2020 | 78 | |
| 2021 | 54 | |
| 2022 | 35 | |
| 2023 | 43 | |
| 2024 | 59 | |
| 2025 | 30 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #105 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.