Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
2,029
Total Reports
130
Deaths Reported
640.0%
Death Rate
7.4 yr
Avg Age at Report
Average weight at time of report: 24.8 kg (54.7 lbs)
Top Reported Reactions
Vomiting 337
Emesis 184
INEFFECTIVE, HEARTWORM LARVAE 183
Lethargy (see also Central nervous system depression in 'Neurological') 180
Diarrhoea 147
Lack of efficacy - NOS 133
Lack of efficacy (ectoparasite) - flea 106
Lack of efficacy (endoparasite) - heartworm 100
Anorexia 92
Seizure NOS 70
Death by euthanasia 69
Other abnormal test result NOS 62
Ataxia 60
Pruritus 58
Lack of efficacy (endoparasite) - hookworm 57
Most Referenced Drugs
Milbemycin Oxime + Spinosad 419
Ivermectin + Pyrantel As Pamoate Salt 162
Spinosad 159
Carprofen 91
Afoxolaner 87
Moxidectin 77
Bedinvetmab 73
Oclacitinib Maleate 65
Fluralaner Chew Tablets 64
Pyrantel Pamoate;Sarolaner 63
Grapiprant 56
Milbemycin Oxime + Praziquantel 52
Selamectin 50
Trilostane 50
Gabapentin 40
Outcome Breakdown
Outcome Unknown
605 (32.2%)
Recovered/Normal
598 (31.8%)
Ongoing
416 (22.1%)
Recovered with Sequela
130 (6.9%)
Died
69 (3.7%)
Euthanized
61 (3.2%)
Gender Distribution
Male 1,015 (50.0%)
Female 981 (48.3%)
Unknown 25 (1.2%)
Mixed 8 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 96 | |
| 2011 | 134 | |
| 2012 | 226 | |
| 2013 | 174 | |
| 2014 | 174 | |
| 2015 | 171 | |
| 2016 | 162 | |
| 2017 | 186 | |
| 2018 | 146 | |
| 2019 | 100 | |
| 2020 | 85 | |
| 2021 | 74 | |
| 2022 | 78 | |
| 2023 | 76 | |
| 2024 | 99 | |
| 2025 | 48 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #80 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.