Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
1,622
Total Reports
40
Deaths Reported
250.0%
Death Rate
5.4 yr
Avg Age at Report
Average weight at time of report: 12.0 kg (26.5 lbs)
Top Reported Reactions
Vomiting 336
Lethargy (see also Central nervous system depression in 'Neurological') 196
Diarrhoea 145
Emesis 122
Seizure NOS 107
Lack of efficacy - NOS 84
Behavioural disorder NOS 74
Anorexia 68
Ataxia 64
Lack of efficacy (ectoparasite) - flea 64
Lack of efficacy (endoparasite) - hookworm 63
Panting 53
Shaking 49
Other abnormal test result NOS 38
Digestive tract disorder NOS 38
Most Referenced Drugs
Milbemycin Oxime + Spinosad 323
Ivermectin + Pyrantel As Pamoate Salt 128
Pyrantel Pamoate;Sarolaner 128
Afoxolaner 127
Oclacitinib Maleate 99
Spinosad 88
Fluralaner Chew Tablets 68
Moxidectin 63
Milbemycin Oxime + Praziquantel 60
Bedinvetmab 48
Fluralaner 13.64% 12-Week Chew 46
Sarolaner 32
Carprofen 30
Cyclosporine 23
Trilostane 23
Outcome Breakdown
Recovered/Normal
588 (38.3%)
Outcome Unknown
457 (29.8%)
Ongoing
407 (26.5%)
Recovered with Sequela
42 (2.7%)
Euthanized
22 (1.4%)
Died
18 (1.2%)
Gender Distribution
Female 799 (49.3%)
Male 779 (48.0%)
Unknown 35 (2.2%)
Mixed 9 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 36 | |
| 2011 | 51 | |
| 2012 | 108 | |
| 2013 | 110 | |
| 2014 | 130 | |
| 2015 | 125 | |
| 2016 | 130 | |
| 2017 | 115 | |
| 2018 | 97 | |
| 2019 | 81 | |
| 2020 | 113 | |
| 2021 | 97 | |
| 2022 | 107 | |
| 2023 | 127 | |
| 2024 | 115 | |
| 2025 | 80 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #84 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.