Total Reports
1,622
FDA CVM filings
Dog /
FDA CVM · 2025 release 1,622 reports on file
Shiba Inu - FDA Adverse Event Profile
Adverse-event records for Shiba Inu (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
With 1,622 reports on file, Shiba Inu sits at #84 among dog breeds by volume; death-coded share is 2.5% (40 reports).
- #84
- most-reported dog breed
- 2.5%
- death-coded report share
- 336
- Vomiting - top reaction
- 5.4 yr
- average age at report
Report counts track breed popularity and reporting activity, not real-world risk, read this alongside how common the breed is.
Deaths Reported
40
of 1,622 reports
Death Rate
2.5%
death-coded share
Avg Age at Report
5.4 yr
12.0 kg avg weight
Death-Coded Outcome Share
Shiba Inu death-coded reports 2.5%
Cross-breed median
2.5% of 1,622 shiba inu reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 12.0 kg (26.5 lbs)
Top Reported Reactions
Vomiting 336
Lethargy (see also Central nervous system depression in 'Neurological') 196
Diarrhoea 145
Emesis 122
Seizure NOS 107
Lack of efficacy - NOS 84
Behavioural disorder NOS 74
Anorexia 68
Ataxia 64
Lack of efficacy (ectoparasite) - flea 64
Lack of efficacy (endoparasite) - hookworm 63
Panting 53
Shaking 49
Other abnormal test result NOS 38
Digestive tract disorder NOS 38
Most Referenced Drugs
Milbemycin Oxime + Spinosad 323
Ivermectin + Pyrantel As Pamoate Salt 128
Pyrantel Pamoate;Sarolaner 128
Afoxolaner 127
Oclacitinib Maleate 99
Spinosad 88
Fluralaner Chew Tablets 68
Moxidectin 63
Milbemycin Oxime + Praziquantel 60
Bedinvetmab 48
Fluralaner 13.64% 12-Week Chew 46
Sarolaner 32
Carprofen 30
Cyclosporine 23
Trilostane 23
Outcome Breakdown
Recovered/Normal
588 (38.3%)
Outcome Unknown
457 (29.8%)
Ongoing
407 (26.5%)
Recovered with Sequela
42 (2.7%)
Euthanized
22 (1.4%)
Died
18 (1.2%)
Gender Distribution
Female 799 (49.3%)
Male 779 (48.0%)
Unknown 35 (2.2%)
Mixed 9 (0.6%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 36 | |
| 2011 | 51 | |
| 2012 | 108 | |
| 2013 | 110 | |
| 2014 | 130 | |
| 2015 | 125 | |
| 2016 | 130 | |
| 2017 | 115 | |
| 2018 | 97 | |
| 2019 | 81 | |
| 2020 | 113 | |
| 2021 | 97 | |
| 2022 | 107 | |
| 2023 | 127 | |
| 2024 | 115 | |
| 2025 | 80 | |
Shiba Inu Pet Health Insights
Shiba Inu accounts for 1,622 FDA adverse event reports, ranking #84 by volume among dog breeds, with 40 reports (2.5%) coded as a death outcome. Mean age at report: 5.4 years, average weight 12.0 kg (26.5 lbs).
Top reported signs: Vomiting (336), Lethargy (see also Central nervous system depression in 'Neurological') (196), Diarrhoea (145). Most-referenced drug: Milbemycin Oxime + Spinosad (323 reports), followed by Ivermectin + Pyrantel As Pamoate Salt (128) and Pyrantel Pamoate;Sarolaner (128).
Outcome coding on 1,534 status-recorded reports is dominated by Recovered/Normal (38.3%). Annual submissions ranged 2,010-2,025 across 16 years on file.
Dog Breeds With a Similar Report Volume
Shepherd Dog - Belgian Malinois
1,623 reports · 3.0% death rate
Terrier - Irish Soft-coated Wheaten
1,617 reports · 3.2% death rate
Corgi - Welsh Pembroke
1,555 reports · 4.2% death rate
Pointer (unspecified)
1,533 reports · 2.7% death rate
Pointing Dog - Hungarian Short-haired (Vizsla)
1,468 reports · 4.0% death rate
Terrier - Scottish
1,461 reports · 5.8% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Shiba Inu? ▼
There are 1,622 adverse event reports involving Shiba Inu in the FDA database, with 40 reports involving death (2.5% death rate). Shiba Inu ranks #84 by report volume.
What are the most common adverse reactions reported for Shiba Inu? ▼
The most commonly reported adverse reactions for Shiba Inu are Vomiting (336 reports), Lethargy (see also Central nervous system depression in 'Neurological') (196 reports), Diarrhoea (145 reports), Emesis (122 reports), Seizure NOS (107 reports).
What drugs are most frequently associated with Shiba Inu adverse events? ▼
The drugs most frequently referenced in Shiba Inu adverse event reports are Milbemycin Oxime + Spinosad (323 reports), Ivermectin + Pyrantel As Pamoate Salt (128 reports), Pyrantel Pamoate;Sarolaner (128 reports), Afoxolaner (127 reports), Oclacitinib Maleate (99 reports).
What is the average age of Shiba Inu in adverse event reports? ▼
The average age of Shiba Inu at the time of adverse event reports is 5.4 years, with an average weight of 12.0 kg (26.5 lbs).
Does a high number of adverse event reports mean Shiba Inu is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Shiba Inu safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.