Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
67
Total Reports
5
Deaths Reported
750.0%
Death Rate
3.6 yr
Avg Age at Report
Average weight at time of report: 50.9 kg (112.2 lbs)
Top Reported Reactions
Vomiting 9
Lack of efficacy (ectoparasite) - flea 8
Emesis 7
Lethargy (see also Central nervous system depression in 'Neurological') 7
Diarrhoea 6
Underdose 5
Lack of efficacy - NOS 4
Ataxia 4
Anorexia 3
Weakness 3
INEFFECTIVE, HEARTWORM LARVAE 3
Lack of efficacy (endoparasite) - hookworm 3
Decreased appetite 3
Seizure NOS 3
Bloody diarrhoea 3
Most Referenced Drugs
Milbemycin Oxime + Spinosad 11
Spinosad 10
Moxidectin 6
Fluralaner Chew Tablets 6
Pyrantel Pamoate;Sarolaner 5
Trilostane 4
Bedinvetmab 4
Lufenuron + Milbemycin Oxime 3
Ivermectin 2
Nitenpyram 2
Fenbendazol Granules 2
Ivermectin + Pyrantel As Pamoate Salt 2
Oclacitinib Maleate 2
Tramadol 2
Fluralaner 13.64% 12-Week Chew 2
Outcome Breakdown
Recovered/Normal
26 (38.8%)
Ongoing
18 (26.9%)
Outcome Unknown
14 (20.9%)
Recovered with Sequela
4 (6.0%)
Died
4 (6.0%)
Euthanized
1 (1.5%)
Gender Distribution
Male 33 (49.3%)
Female 32 (47.8%)
Mixed 1 (1.5%)
Unknown 1 (1.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2012 | 4 | |
| 2013 | 8 | |
| 2014 | 5 | |
| 2015 | 9 | |
| 2016 | 7 | |
| 2017 | 4 | |
| 2018 | 3 | |
| 2019 | 3 | |
| 2020 | 1 | |
| 2021 | 8 | |
| 2022 | 4 | |
| 2023 | 4 | |
| 2024 | 5 | |
| 2025 | 1 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #252 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.