Total Reports
67
FDA CVM filings
Dog /
FDA CVM · 2025 release 67 reports on file
Mastiff - Neapolitan - FDA Adverse Event Profile
Adverse-event records for Mastiff - Neapolitan (Dog) from the FDA Center for Veterinary Medicine.
Data updated June 2026
The record at a glance
Mastiff - Neapolitan ranks #252 by report volume among dog breeds - 5 of 67 reports (7.5%) recorded a death outcome.
- #252
- most-reported dog breed
- 7.5%
- death-coded report share
- 9
- Vomiting - top reaction
- 3.6 yr
- average age at report
Read report counts next to breed popularity: a bigger number often just means more owners and more vet visits.
Deaths Reported
5
of 67 reports
Death Rate
7.5%
death-coded share
Avg Age at Report
3.6 yr
50.9 kg avg weight
Death-Coded Outcome Share
Mastiff - Neapolitan death-coded reports 7.5%
Cross-breed median
7.5% of 67 mastiff - neapolitan reports involved a death outcome.
How to read this number
Read alongside breed popularity, veterinary access, and owner awareness, these shape how many events ever reach the FDA. The comparison line marks the cross-breed median death-coded share (about 4.8%) among breeds with 50 or more reports; values above it suggest higher reporting bias toward severe outcomes, not necessarily higher true mortality.
Average weight at time of report: 50.9 kg (112.2 lbs)
Top Reported Reactions
Vomiting 9
Lack of efficacy (ectoparasite) - flea 8
Emesis 7
Lethargy (see also Central nervous system depression in 'Neurological') 7
Diarrhoea 6
Most Referenced Drugs
Milbemycin Oxime + Spinosad 11
Spinosad 10
Moxidectin 6
Fluralaner Chew Tablets 6
Pyrantel Pamoate;Sarolaner 5
Outcome Breakdown
Recovered/Normal
26 (38.8%)
Ongoing
18 (26.9%)
Outcome Unknown
14 (20.9%)
Recovered with Sequela
4 (6.0%)
Died
4 (6.0%)
Euthanized
1 (1.5%)
Gender Distribution
Male 33 (49.3%)
Female 32 (47.8%)
Mixed 1 (1.5%)
Unknown 1 (1.5%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 1 | |
| 2012 | 4 | |
| 2013 | 8 | |
| 2014 | 5 | |
| 2015 | 9 | |
| 2016 | 7 | |
| 2017 | 4 | |
| 2018 | 3 | |
| 2019 | 3 | |
| 2020 | 1 | |
| 2021 | 8 | |
| 2022 | 4 | |
| 2023 | 4 | |
| 2024 | 5 | |
| 2025 | 1 | |
Mastiff - Neapolitan Pet Health Insights
Mastiff - Neapolitan accounts for 67 FDA adverse event reports, ranking #252 by volume among dog breeds, with 5 reports (7.5%) coded as a death outcome. Mean age at report: 3.6 years, average weight 50.9 kg (112.2 lbs).
Top reported signs: Vomiting (9), Lack of efficacy (ectoparasite) - flea (8), Emesis (7). Most-referenced drug: Milbemycin Oxime + Spinosad (11 reports), followed by Spinosad (10) and Moxidectin (6).
Outcome coding on 67 status-recorded reports is dominated by Recovered/Normal (38.8%). Annual submissions ranged 2,010-2,025 across 15 years on file.
Dog Breeds With a Similar Report Volume
Carolina Dog
69 reports · 7.2% death rate
Chinese Crested Dog – Powder Puff with veil coat
65 reports · 3.1% death rate
Spaniel - Clumber
69 reports · 1.4% death rate
Spaniel - Field
69 reports · 2.9% death rate
Chinese Crested Dog – Hairless
64 reports · 3.1% death rate
Saluki
64 reports · 1.6% death rate
Frequently Asked Questions
How many FDA adverse event reports involve Mastiff - Neapolitan? ▼
There are 67 adverse event reports involving Mastiff - Neapolitan in the FDA database, with 5 reports involving death (7.5% death rate). Mastiff - Neapolitan ranks #252 by report volume.
What are the most common adverse reactions reported for Mastiff - Neapolitan? ▼
The most commonly reported adverse reactions for Mastiff - Neapolitan are Vomiting (9 reports), Lack of efficacy (ectoparasite) - flea (8 reports), Emesis (7 reports), Lethargy (see also Central nervous system depression in 'Neurological') (7 reports), Diarrhoea (6 reports).
What drugs are most frequently associated with Mastiff - Neapolitan adverse events? ▼
The drugs most frequently referenced in Mastiff - Neapolitan adverse event reports are Milbemycin Oxime + Spinosad (11 reports), Spinosad (10 reports), Moxidectin (6 reports), Fluralaner Chew Tablets (6 reports), Pyrantel Pamoate;Sarolaner (5 reports).
What is the average age of Mastiff - Neapolitan in adverse event reports? ▼
The average age of Mastiff - Neapolitan at the time of adverse event reports is 3.6 years, with an average weight of 50.9 kg (112.2 lbs).
Does a high number of adverse event reports mean Mastiff - Neapolitan is unhealthy? ▼
No. FDA adverse event reports are voluntarily submitted and do not prove causation. Popular breeds with more veterinary visits tend to have more reports. The data reflects reporting patterns, not actual incidence rates. Always consult a veterinarian for health decisions.
Where does this Mastiff - Neapolitan safety data come from? ▼
All data comes from the FDA Center for Veterinary Medicine's adverse event reporting system. Pet owners, veterinarians, and manufacturers voluntarily submit reports about adverse events potentially linked to animal drugs and other products.
Compare a breed's report volume against how common the breed is before drawing conclusions. See our methodology for how death rate and rankings are computed.
Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. Breed figures are computed directly from FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.