Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
4,095
Total Reports
190
Deaths Reported
460.0%
Death Rate
6.4 yr
Avg Age at Report
Average weight at time of report: 6.1 kg (13.5 lbs)
Top Reported Reactions
Vomiting 925
Lethargy (see also Central nervous system depression in 'Neurological') 577
Emesis 365
Diarrhoea 337
Lack of efficacy (ectoparasite) - flea 272
Anorexia 183
Lack of efficacy - NOS 180
Seizure NOS 173
Lack of efficacy (endoparasite) - hookworm 171
Behavioural disorder NOS 135
Other abnormal test result NOS 129
Emesis (multiple) 129
Digestive tract disorder NOS 128
Not eating 122
Decreased appetite 108
Most Referenced Drugs
Milbemycin Oxime + Spinosad 865
Trilostane 468
Ivermectin + Pyrantel As Pamoate Salt 363
Afoxolaner 303
Fluralaner Chew Tablets 220
Pyrantel Pamoate;Sarolaner 206
Moxidectin 200
Spinosad 200
Fluralaner 13.64% 12-Week Chew 112
Milbemycin Oxime + Praziquantel 102
Oclacitinib Maleate 99
Carprofen 90
Nitenpyram 85
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 81
Imidacloprid + Moxidectin 80
Outcome Breakdown
Recovered/Normal
1,502 (36.6%)
Outcome Unknown
1,413 (34.5%)
Ongoing
854 (20.8%)
Recovered with Sequela
141 (3.4%)
Died
98 (2.4%)
Euthanized
92 (2.2%)
Gender Distribution
Female 2,268 (55.4%)
Male 1,721 (42.0%)
Unknown 88 (2.1%)
Mixed 18 (0.4%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 8 | |
| 2011 | 76 | |
| 2012 | 272 | |
| 2013 | 345 | |
| 2014 | 416 | |
| 2015 | 435 | |
| 2016 | 375 | |
| 2017 | 396 | |
| 2018 | 292 | |
| 2019 | 264 | |
| 2020 | 229 | |
| 2021 | 204 | |
| 2022 | 178 | |
| 2023 | 207 | |
| 2024 | 223 | |
| 2025 | 175 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #48 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.