Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
142
Total Reports
4
Deaths Reported
280.0%
Death Rate
6.2 yr
Avg Age at Report
Average weight at time of report: 7.0 kg (15.4 lbs)
Top Reported Reactions
Vomiting 35
Lethargy (see also Central nervous system depression in 'Neurological') 21
Emesis 16
Diarrhoea 15
Lack of efficacy (ectoparasite) - flea 13
Lack of efficacy - NOS 7
Lack of efficacy (endoparasite) - hookworm 6
Shaking 6
Digestive tract disorder NOS 5
Other abnormal test result NOS 5
Seizure NOS 5
Overdose 5
Depression 4
Ataxia 4
Panting 4
Most Referenced Drugs
Milbemycin Oxime + Spinosad 37
Spinosad 15
Ivermectin + Pyrantel As Pamoate Salt 11
Fluralaner 13.64% 12-Week Chew 11
Afoxolaner 8
Fluralaner Chew Tablets 6
Pyrantel Pamoate;Sarolaner 6
Oclacitinib Maleate 5
Selamectin 4
Milbemycin Oxime, Lufenuron 4
Ivermectin/Pyrantel Pamoate Chewable 68Mcg/163Mg 3
Lufenuron + Milbemycin Oxime 3
Imidacloprid + Moxidectin 3
Milbemycin Oxime + Praziquantel 3
Carprofen 3
Outcome Breakdown
Recovered/Normal
68 (50.4%)
Outcome Unknown
35 (25.9%)
Ongoing
24 (17.8%)
Recovered with Sequela
4 (3.0%)
Euthanized
3 (2.2%)
Died
1 (0.7%)
Gender Distribution
Male 74 (52.1%)
Female 64 (45.1%)
Unknown 3 (2.1%)
Mixed 1 (0.7%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 3 | |
| 2011 | 6 | |
| 2012 | 10 | |
| 2013 | 11 | |
| 2014 | 15 | |
| 2015 | 15 | |
| 2016 | 11 | |
| 2017 | 11 | |
| 2018 | 11 | |
| 2019 | 7 | |
| 2020 | 6 | |
| 2021 | 7 | |
| 2022 | 9 | |
| 2023 | 6 | |
| 2024 | 9 | |
| 2025 | 5 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #211 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.