Important: Adverse event reports are voluntarily submitted and do not prove causation. Consult your veterinarian for medical decisions about your dog.
3,154
Total Reports
114
Deaths Reported
360.0%
Death Rate
7.4 yr
Avg Age at Report
Average weight at time of report: 8.3 kg (18.3 lbs)
Top Reported Reactions
Vomiting 715
Emesis 438
Lethargy (see also Central nervous system depression in 'Neurological') 315
Lack of efficacy (ectoparasite) - flea 260
Diarrhoea 247
Lack of efficacy - NOS 181
Anorexia 148
Seizure NOS 110
Pruritus 100
Lack of efficacy (endoparasite) - hookworm 97
Lack of efficacy (tick) 79
Decreased appetite 77
Other abnormal test result NOS 77
Behavioural disorder NOS 73
Lack of efficacy (flea) 73
Most Referenced Drugs
Milbemycin Oxime + Spinosad 658
Spinosad 364
Oclacitinib Maleate 181
Afoxolaner 159
Ivermectin + Pyrantel As Pamoate Salt 155
Fluralaner Chew Tablets 147
Afoxolaner 28.3 Mg Chewable Tablets 131
Trilostane 121
Moxidectin 80
Pyrantel Pamoate;Sarolaner 74
Selamectin 67
Carprofen 63
Sarolaner 61
Cyclosporine A 56
Fluralaner 13.64% 12-Week Chew 56
Outcome Breakdown
Recovered/Normal
1,186 (41.4%)
Outcome Unknown
862 (30.1%)
Ongoing
573 (20.0%)
Recovered with Sequela
133 (4.6%)
Died
61 (2.1%)
Euthanized
53 (1.8%)
Gender Distribution
Male 1,685 (53.4%)
Female 1,405 (44.5%)
Unknown 56 (1.8%)
Mixed 8 (0.3%)
Reports by Year
| Year | Reports | Trend |
|---|---|---|
| 2010 | 161 | |
| 2011 | 227 | |
| 2012 | 344 | |
| 2013 | 326 | |
| 2014 | 281 | |
| 2015 | 316 | |
| 2016 | 316 | |
| 2017 | 295 | |
| 2018 | 164 | |
| 2019 | 151 | |
| 2020 | 126 | |
| 2021 | 103 | |
| 2022 | 94 | |
| 2023 | 98 | |
| 2024 | 96 | |
| 2025 | 56 | |
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Rank #57 by report volume. Data reflects voluntary submissions and may not represent actual incidence rates.